Apoptosis is a demanding selective tool during the development of fetal male germ cells

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Apoptosis is a demanding selective tool during the development of fetal male germ cells

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Title: Apoptosis is a demanding selective tool during the development of fetal male germ cells
Author: Bejarano Hernando, Ignacio; Rodríguez Moratinos, Ana Beatriz; Pariente Llanos, José Antonio
Abstract: Se sabe que la apoptosis desempeña un papel importante en las enfermedades relacionadas con la infertilidad masculina. Las enfermedades del tracto genital masculino como la espermatogénesis defectuosa, la disminución de la motilidad del esperma, la fragmentación del ADN del esperma, la torsión testicular, el varicocele y la infertilidad inmunológica están fuertemente relacionadas con la muerte celular apoptótica. La apoptosis no debe considerarse únicamente como un fallo en la fisiología de las células germinales o un efecto secundario de ciertas patologías y agentes peligrosos exógenos. La apoptosis orquesta la función y el desarrollo correctos de la célula germinal masculina desde las primeras etapas embrionarias de la diferenciación gonadal hasta la fecundación. En esta revisión hemos tratado de abordar un marco de lectura de los principales conocimientos sobre la apoptosis en el desarrollo de las células germinales masculinas. Centrándonos en los mecanismos relativos a la apoptosis celular, que son independientes de los estímulos exógenos, hemos tratado de poner de relieve que la apoptosis es un instrumento selectivo que garantiza la transmisión del mensaje genético a la descendencia.Apoptosis is widely known to play a major role on diseases related to male infertility. Diseases of the male genital tract as defective spermatogenesis, decreased sperm motility, sperm DNA fragmentation, testicular torsion, varicocele and immunological infertility are strongly related to apoptotic cell death. Apoptosis must not be considered only as a fail on germ cell physiology or a secondary effect of certain pathologies and exogenous hazardous agents. Apoptosis orchestrates correct function and development of the male germ cell from the early embryonic stages of gonadal differentiation to the fertilization. In this review we have tried to address a reading frame of the main knowledge about apoptosis in male germ cell development. Focussing on mechanisms concerning cellular apoptosis, which are independent of exogenous stimuli, we aimed to highlight that apoptosis is a selective instrument that guarantees the delivery of genetic message to offspring.
URI: http://hdl.handle.net/10662/10225
Date: 2018


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