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http://hdl.handle.net/10662/19853
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Campo DC | Valor | idioma |
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dc.contributor.author | Martín Cano, Francisco Eduardo | - |
dc.contributor.author | Camello Almaraz, María Cristina | - |
dc.contributor.author | González Macías, Jesús | - |
dc.contributor.author | Pozo Andrada, María José | - |
dc.contributor.author | Camello Almaraz, Pedro Javier | - |
dc.date.accessioned | 2024-02-04T17:17:37Z | - |
dc.date.available | 2024-02-04T17:17:37Z | - |
dc.date.issued | 2016 | - |
dc.identifier.uri | http://hdl.handle.net/10662/19853 | - |
dc.description.abstract | There is little information on the effects of aging in the propagation of calcium signals and its underlying mechanisms. We studied the effects of aging on propagation of Ca2+ signals in pancreatic acinar cells. Fura-2 loaded cells isolated from young (3–4 months old) and aged (24 months old) mouse responded to acetylcholine (ACh) and cholecystokinin (CCK) with a polarized Ca2+ response initiated at the secretory pole before spreading to the basal one. Aging slowed down the propagation of the response to ACh but enhanced the velocity of the CCK response. This pattern can be explained by the age-induced depolarization of mitochondria, because it can be reproduced in young cells by mitochondrial inhibitors. Aging also increased the role of acidic stores in the CCK signal, as judged by the folimycin-induced suppression of the polarization in aged but not in young cells. The involvement of ryanodine receptors in the ACh response was also enhanced, as indicated by the loss of polarization after the treatment with 8Br–cyclic ADP ribose. Therefore, we conclude that aging modifies differentially the propagation of ACh and CCK-evoked Ca2+ signals through mitochondrial depolarization and changes in the role of the acidic Ca2+ stores and ryanodine receptors in the initiation of the signals | es_ES |
dc.description.sponsorship | This study was supported by Ministerio de Ciencia e Innovación, Spain (BFU2011-24365); Red Temática de Investigación en Envejecimiento y Fragilidad (RETICEF RD12/0043/0016 and RETICEF RD06/0013/1007); Fondo Europeo de Desarrollo Regional (FEDER); and Junta de Extremadura, Spain (GR10009). | es_ES |
dc.format.extent | 8 p. | es_ES |
dc.format.mimetype | application/pdf | en_US |
dc.language.iso | eng | es_ES |
dc.publisher | Oxford University Press | es_ES |
dc.rights | Attribution-NonCommercial 4.0 International | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | - |
dc.subject | Calcium signaling | es_ES |
dc.subject | Señal de calcio | es_ES |
dc.subject | Exocrine pancreas | es_ES |
dc.subject | Páncreas exocrino | es_ES |
dc.subject | Mitochondria | es_ES |
dc.subject | Mitocondria | es_ES |
dc.subject | Mouse | eng_US |
dc.subject | Ratones | es_ES |
dc.title | Propagation of Intracellular Ca2+ Signals in Aged Exocrine Cells | es_ES |
dc.type | article | es_ES |
dc.description.version | peerReviewed | es_ES |
europeana.type | TEXT | en_US |
dc.rights.accessRights | openAccess | es_ES |
dc.subject.unesco | 2411.04 Fisiología Endocrina | es_ES |
europeana.dataProvider | Universidad de Extremadura. España | es_ES |
dc.identifier.bibliographicCitation | Francisco E. Martin-Cano, Cristina Camello-Almaraz, Jesús González Macías, Maria J. Pozo, Pedro J. Camello, Propagation of Intracellular Ca 2+ Signals in Aged Exocrine Cells , The Journals of Gerontology: Series A, Volume 71, Issue 2, February 2016, Pages 145–152, https://doi.org/10.1093/gerona/glv018 | es_ES |
dc.type.version | publishedVersion | es_ES |
dc.contributor.affiliation | Universidad de Extremadura. Departamento de Fisiología | es_ES |
dc.contributor.affiliation | Hospital Marqués de Valdecilla (Santander) | es_ES |
dc.relation.publisherversion | https://academic.oup.com/biomedgerontology/article/71/2/145/2605617 | es_ES |
dc.identifier.doi | 10.1093/gerona/glv018 | - |
dc.identifier.publicationtitle | Journals of Gerontology: Biological Sciences | es_ES |
dc.identifier.publicationissue | 71 | es_ES |
dc.identifier.publicationfirstpage | 145 | es_ES |
dc.identifier.publicationlastpage | 152 | es_ES |
dc.identifier.publicationvolume | 2 | es_ES |
dc.identifier.orcid | 0000-0003-0882-8497 | es_ES |
dc.identifier.orcid | 0000-0003-4971-4883 | es_ES |
dc.identifier.orcid | 0000-0002-5423-5097 | es_ES |
dc.identifier.orcid | 0000-0002-4137-6798 | es_ES |
dc.identifier.orcid | 0000-0001-5026-7166 | es_ES |
Colección: | DFSIO - Artículos |
Archivos
Archivo | Descripción | Tamaño | Formato | |
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gerona_glv018.pdf | 8,71 MB | Adobe PDF | Descargar |
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