Identificador persistente para citar o vincular este elemento:
http://hdl.handle.net/10662/19858
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Campo DC | Valor | idioma |
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dc.contributor.author | Bravo San Pedro, José Manuel | - |
dc.contributor.author | Sica, Valentina | - |
dc.contributor.author | Martins, Isabelle | - |
dc.contributor.author | Pol, Jonathan | - |
dc.contributor.author | Loos, Friedemann | - |
dc.contributor.author | Maiuri, Maria Chiara | - |
dc.contributor.author | Durand, Sylvere | - |
dc.contributor.author | Bossut, Noélie | - |
dc.contributor.author | Anagnostopoulos, Gerasimos | - |
dc.contributor.author | Niso Santano, Mireia | - |
dc.contributor.author | Drake Aranda, Fernando | - |
dc.contributor.author | Ramirez Pardo, Ignacio | - |
dc.contributor.author | Denom, Justine | - |
dc.contributor.author | Boedec, Erwan | - |
dc.contributor.author | Gorwood, Philip | - |
dc.contributor.author | Ramoz, Nicolas | - |
dc.contributor.author | Clément, Karine | - |
dc.contributor.author | Pelloux, Veronique | - |
dc.contributor.author | Rohia, Alili | - |
dc.contributor.author | Pattou, François | - |
dc.contributor.author | Raverdy, Violeta | - |
dc.contributor.author | Caiazzo, Robert | - |
dc.contributor.author | Denis, Raphaël G.P. | - |
dc.contributor.author | Boya, Patricia | - |
dc.contributor.author | Galluzzi, Lorenzo | - |
dc.contributor.author | Madeo, Frank | - |
dc.contributor.author | Migrenne Li, Stéphanie | - |
dc.contributor.author | Cruciani Guglielmacci, Céline | - |
dc.contributor.author | Tavernarakis, Nektarios | - |
dc.contributor.author | López Otín, Carlos | - |
dc.contributor.author | Magnan, Christophe | - |
dc.contributor.author | Kroemer, Guido | - |
dc.date.accessioned | 2024-02-04T20:21:25Z | - |
dc.date.available | 2024-02-04T20:21:25Z | - |
dc.date.issued | 2019 | - |
dc.identifier.uri | http://hdl.handle.net/10662/19858 | - |
dc.description.abstract | Autophagy facilitates the adaptation to nutritional stress. Here, we show that short-term starvation of cultured cells or mice caused the autophagy-dependent cellular release of acyl-CoA-binding protein (ACBP, also known as diazepam-binding inhibitor, DBI) and consequent ACBP-mediated feedback inhibition of autophagy. Importantly, ACBP levels were elevated in obese patients and reduced in anorexia nervosa. In mice, systemic injection of ACBP protein inhibited autophagy, induced lipogenesis, reduced glycemia, and stimulated appetite as well as weight gain. We designed three approaches to neutralize ACBP, namely, inducible whole-body knockout, systemic administration of neutralizing antibodies, and induction of antiACBP autoantibodies in mice. ACBP neutralization enhanced autophagy, stimulated fatty acid oxidation, inhibited appetite, reduced weight gain in the context of a high-fat diet or leptin deficiency, and accelerated weight loss in response to dietary changes. In conclusion, neutralization of ACBP might constitute a strategy for treating obesity and its co-morbidities. | es_ES |
dc.description.sponsorship | C.L.-O. is supported by “Juan de Madariaga fellowship”; S.B. is supported by the Swedish Research Council Vetenskapsrådet (2015-05468) and the Austrian Science Fund FWF (P27183-B24); and F.M. is supported by the Austrian Science Fund FWF (grants P23490-B20, P29262, P24381, P29203, and P27893), DKplus Metabolic and Cardiovascular Diseases (W1226), Austrian Science Ministry, Karl Franzens University (“Unkonventionelle Forschung” and “flysleep”), NAWI Graz, and BioTechMed-Graz flagship project “EPIAge.” K.C. is supported by ANR MICRO-Obes and AP/HP (PHRC Microbaria). L.G. is supported by an intramural startup from the Department of Radiation Oncology of Weill Cornell Medical College (New York, US) and by Sotio a.c. (Prague, Czech Republic). | - |
dc.format.extent | 41 p. | es_ES |
dc.format.mimetype | application/pdf | en_US |
dc.language.iso | eng | es_ES |
dc.publisher | Sciendirect | - |
dc.subject | Anorexia | es_ES |
dc.subject | Anorexy | es_ES |
dc.subject | Autofagia | es_ES |
dc.subject | Autophagy | es_ES |
dc.subject | Obesidad | es_ES |
dc.subject | Obesity | es_ES |
dc.subject | Lipid metabolism | - |
dc.subject | Metabolismo de los lípidos | - |
dc.title | Acyl-CoA-Binding protein is a lipogenic factor that triggers food intake and obesity | es_ES |
dc.type | article | es_ES |
dc.description.version | peerReviewed | es_ES |
europeana.type | TEXT | en_US |
dc.rights.accessRights | closedAccess | es_ES |
dc.subject.unesco | 3206.10 Enfermedades de la Nutrición | es_ES |
dc.subject.unesco | 3302.90 Ingeniería Bioquímica | es_ES |
dc.subject.unesco | 2403 Bioquímica | es_ES |
europeana.dataProvider | Universidad de Extremadura. España | es_ES |
dc.identifier.bibliographicCitation | Bravo-San Pedro JM, Sica V, Martins I, Pol J, Loos F, Maiuri MC, Durand S, Bossut N, Aprahamian F, Anagnostopoulos G, Niso-Santano M, Aranda F, Ramírez-Pardo I, Lallement J, Denom J, Boedec E, Gorwood P, Ramoz N, Clément K, Pelloux V, Rohia A, Pattou F, Raverdy V, Caiazzo R, Denis RGP, Boya P, Galluzzi L, Madeo F, Migrenne-Li S, Cruciani-Guglielmacci C, Tavernarakis N, López-Otín C, Magnan C, Kroemer G. Acyl-CoA-Binding Protein Is a Lipogenic Factor that Triggers Food Intake and Obesity. Cell Metab. 2019 Oct 1;30(4):754-767.e9. doi: 10.1016/j.cmet.2019.07.010. Epub 2019 Aug 15. Erratum in: Cell Metab. 2019 Dec 3;30(6):1171. PMID: 31422903. | es_ES |
dc.type.version | publishedVersion | es_ES |
dc.contributor.affiliation | Universidad de Extremadura. Departamento de Bioquímica, Biología Molecular y Genética | es_ES |
dc.contributor.affiliation | Université Paris Saclay. France | - |
dc.contributor.affiliation | CSIC-Centro de Investigaciones Biológicas | - |
dc.contributor.affiliation | Université Paris Diderot. France | - |
dc.contributor.affiliation | Université de Lille. Francia | - |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S1550413119303833 | es_ES |
dc.identifier.doi | 10.1016/j.cmet.2019.07.010 | - |
dc.identifier.publicationtitle | Cell Metabolism | es_ES |
dc.identifier.publicationissue | 30 | es_ES |
dc.identifier.publicationfirstpage | 754 | es_ES |
dc.identifier.publicationlastpage | 767 | es_ES |
dc.identifier.publicationvolume | 4 | es_ES |
dc.identifier.orcid | 0000-0002-6506-422X | es_ES |
Colección: | DBYBM - Artículos |
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