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http://hdl.handle.net/10662/20104
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Campo DC | Valor | idioma |
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dc.contributor.author | Ayuso Parejo, Pedro | - |
dc.contributor.author | Blanca, Miguel | - |
dc.contributor.author | Cornejo García, José Antonio | - |
dc.contributor.author | Torres, María José | - |
dc.contributor.author | Doña, Inmaculada | - |
dc.contributor.author | Salas, María | - |
dc.contributor.author | Blanca López, Natalia | - |
dc.contributor.author | Canto Díez, Gabriela | - |
dc.contributor.author | Rondón, Carmen | - |
dc.contributor.author | Campo, Paloma | - |
dc.contributor.author | Laguna, José J. | - |
dc.contributor.author | Fernández, Javier | - |
dc.contributor.author | Martínez, Carmen | - |
dc.contributor.author | García-Agúndez Pérez-Coca, José Augusto | - |
dc.contributor.author | García Martín, Elena | - |
dc.date.accessioned | 2024-02-07T07:38:27Z | - |
dc.date.available | 2024-02-07T07:38:27Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 2769-6456 | - |
dc.identifier.uri | http://hdl.handle.net/10662/20104 | - |
dc.description.abstract | Histamine plays an important role in the pathogenesis of allergic diseases. Genetic variations in histamine receptors (HRH) may influence the expression of allergic diseases. This study analyzes the association between HRH variants and NSAID hypersensitivity reactions. Patients & methods: The authors analyzed copy number variations (CNVs) and common functional SNPs in genes HRH1, HRH2 and HRH4 in 442 unrelated patients with hypersensitivity to NSAIDs and in 414 healthy unrelated controls. Results: The authors identified, both in patients and control subjects, individuals carrying CNVs in HRH genes. The most common genotype corresponded to two copies of each gene, but carriers of one or three copies of HRH1 (5% of individuals), HRH2 (1.1%) and HRH4 genes (0.9%) were also identified. Conclusion: For the first time, we describe CNVs in human HRH genes. Neither common functional SNPs in HRH genes nor CNVs influenced the risk of developing hypersensitivity to NSAIDs. | es_ES |
dc.format.extent | 8 | es_ES |
dc.format.mimetype | application/pdf | en_US |
dc.language.iso | eng | es_ES |
dc.publisher | Future Medicine | es_ES |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | histamina, reacciones de hipersensibilidad, polimorfismos | es_ES |
dc.subject | histamine, hypersensibility reactions, polymorphisms | es_ES |
dc.title | Variability in histamine receptor genes HRH1, HRH2 and HRH4 in patients with hypersensitivity to NSAIDs | es_ES |
dc.type | article | es_ES |
dc.description.version | peerReviewed | es_ES |
europeana.type | TEXT | en_US |
dc.rights.accessRights | openAccess | es_ES |
dc.subject.unesco | 3209 Farmacología | es_ES |
dc.subject.unesco | 2302 Bioquímica | es_ES |
europeana.dataProvider | Universidad de Extremadura. España | es_ES |
dc.type.version | publishedVersion | es_ES |
dc.contributor.affiliation | Universidad de Extremadura. Departamento de Terapéutica Médico-Quirúrgica | es_ES |
dc.relation.publisherversion | 10.2217/pgs.13.155 | es_ES |
dc.identifier.publicationtitle | Pharmacogenomics | es_ES |
dc.identifier.publicationissue | 14 | es_ES |
dc.identifier.publicationfirstpage | 1871 | es_ES |
dc.identifier.publicationlastpage | 1878 | es_ES |
dc.identifier.publicationvolume | 15 | es_ES |
Colección: | DTMQU - Artículos |
Archivos
Archivo | Descripción | Tamaño | Formato | |
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pgs_13_155.pdf ???org.dspace.app.webui.jsptag.ItemTag.accessRestricted??? | Variability in histamine receptor genes HRH1, HRH2 and HRH4 in patients with hypersensitivity to NSAIDs | 504,85 kB | Adobe PDF | Descargar Pide una copia |
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