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dc.contributor.authorGarcía-Agúndez Pérez-Coca, José Augusto-
dc.contributor.authorAyuso Parejo, Pedro-
dc.contributor.authorCornejo García, José Antonio-
dc.contributor.authorBlanca Gómez, Miguel-
dc.contributor.authorTorres, María José-
dc.contributor.authorDoña, Inmaculada-
dc.contributor.authorSalas, María-
dc.contributor.authorBlanca López, Natalia-
dc.contributor.authorCanto Diez, María Gabriela-
dc.contributor.authorRondón, Carmen-
dc.contributor.authorCampo Mozo, Paloma-
dc.contributor.authorLaguna Martínez, José Julio-
dc.contributor.authorFernández, Javier-
dc.contributor.authorMartínez, Carmen-
dc.contributor.authorGarcía Martín, Elena-
dc.date.accessioned2024-02-07T08:45:35Z-
dc.date.available2024-02-07T08:45:35Z-
dc.date.issued2012-11-12-
dc.identifier.issn1932-6203-
dc.identifier.urihttp://hdl.handle.net/10662/20140-
dc.description.abstractNon-steroidal anti-inflammatory drugs (NSAIDs) are the drugs most frequently involved in hypersensitivity drug reactions. Histamine is released in the allergic response to NSAIDs and is responsible for some of the clinical symptoms. The aim of this study is to analyze clinical association of functional polymorphisms in the genes coding for enzymes involved in histamine homeostasis with hypersensitivity response to NSAIDs. We studied a cohort of 442 unrelated Caucasian patients with hypersensitivity to NSAIDs. Patients who experienced three or more episodes with two or more different NSAIDs were included. If this requirement was not met diagnosis was established by challenge. A total of 414 healthy unrelated controls ethnically matched with patients and from the same geographic area were recruited. Analyses of the SNPs rs17740607, rs2073440, rs1801105, rs2052129, rs10156191, rs1049742 and rs1049793 in the HDC, HNMT and DAO genes were carried out by means of TaqMan assays. The detrimental DAO 16 Met allele (rs10156191), which causes decreased metabolic capacity, is overrepresented among patients with crossed-hypersensitivity to NSAIDs with an OR = 1.7 (95% CI = 1.3–2.1; Pc = 0.0003) with a gene-dose effect (P = 0.0001). The association was replicated in two populations from different geographic areas (Pc = 0.008 and Pc = 0.004, respectively). Conclusions and implications: The DAO polymorphism rs10156191 which causes impaired metabolism of circulating histamine is associated with the clinical response in crossed-hypersensitivity to NSAIDs and could be used as a biomarker of response.es_ES
dc.format.extent8es_ES
dc.format.mimetypeapplication/pdfen_US
dc.language.isoenges_ES
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectdiamino oxidasa, reacciones de hipersensibilidad, antiinflamatorios no esteroideoses_ES
dc.subjectDiamine oxidase, hypersensitivity reactions, non-steroidal antiinflammatory drugses_ES
dc.titleThe Diamine Oxidase Gene Is Associated with Hypersensitivity Response to Non-Steroidal Anti- Inflammatory Drugses_ES
dc.typearticlees_ES
dc.description.versionpeerReviewedes_ES
europeana.typeTEXTen_US
dc.rights.accessRightsopenAccesses_ES
dc.subject.unesco3209 Farmacologíaes_ES
dc.subject.unesco2302.04 Genética Bioquímicaes_ES
europeana.dataProviderUniversidad de Extremadura. Españaes_ES
dc.type.versionpublishedVersiones_ES
dc.contributor.affiliationUniversidad de Extremadura. Departamento de Terapéutica Médico-Quirúrgicaes_ES
dc.relation.publisherversion10.1371/journal.pone.0047571es_ES
dc.identifier.publicationtitlePLOS ONEes_ES
dc.identifier.publicationissue11es_ES
dc.identifier.publicationfirstpagee47571-1es_ES
dc.identifier.publicationlastpagee47571-8es_ES
dc.identifier.publicationvolume7es_ES
dc.identifier.orcid0000-0002-9441-4022es_ES
dc.identifier.orcid0000-0001-6895-9160es_ES
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