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http://hdl.handle.net/10662/20153
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Campo DC | Valor | idioma |
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dc.contributor.author | Ayuso Parejo, Pedro | - |
dc.contributor.author | Martínez, Carmen | - |
dc.contributor.author | Lorenzo Betancor, Oswaldo | - |
dc.contributor.author | Pastor Muñoz, Pau | - |
dc.contributor.author | Luengo, Antonio | - |
dc.contributor.author | Jiménez Jiménez, Félix Javier | - |
dc.contributor.author | Alonso Navarro, Hortensia | - |
dc.contributor.author | Villalba, María T | - |
dc.contributor.author | García-Agúndez Pérez-Coca, José Augusto | - |
dc.contributor.author | García Martín, Elena | - |
dc.date.accessioned | 2024-02-07T09:07:05Z | - |
dc.date.available | 2024-02-07T09:07:05Z | - |
dc.date.issued | 2011-05-19 | - |
dc.identifier.issn | 1744-6872 | - |
dc.identifier.issn | 1744-6880 | - |
dc.identifier.uri | http://hdl.handle.net/10662/20153 | - |
dc.description.abstract | Aim Oxidative stress and iron deposition is related to Parkinson’s disease (PD). Heme oxygenase 2 (HMOX2) catalyzes the cleavage of the heme ring to form biliverdin with release of iron and carbon monoxide. This study aims to analyze variations in the HMOX2 gene in patients with PD. Materials and methods We mapped four single nucleotide polymorphisms (SNPs) and copy number variations of the HMOX2 gene in 691 patients with PD and 747 healthy individuals. Results We identified a highly homogeneous association of the HMOX2 SNP rs2270363 homozygous G/G genotype with patients with classical PD phenotype compared with healthy individuals. We identified three patients with PD and two control individuals with a single copy of the HMOX2 gene. No individuals with zero or more than two gene copies were identified. Conclusion We describe for the first time, copy number variations in the HMOX2 gene and an association of the SNP rs2270363 with PD risk. | es_ES |
dc.format.extent | 7 | es_ES |
dc.format.mimetype | application/pdf | en_US |
dc.language.iso | eng | es_ES |
dc.publisher | Lippincott Williams & Wilkins | es_ES |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | variaciones número de copias, homoxigenasa 2, Parkinson | es_ES |
dc.subject | copy number variations, heme oxygenase 2, Parkinson | es_ES |
dc.title | A polymorphism located at an ATG transcription start site of the heme oxygenase-2 gene is associated with classical Parkinson’s disease | es_ES |
dc.type | article | es_ES |
dc.description.version | peerReviewed | es_ES |
europeana.type | TEXT | en_US |
dc.rights.accessRights | openAccess | es_ES |
dc.subject.unesco | 3209 Farmacología | es_ES |
dc.subject.unesco | 2302.04 Genética Bioquímica | es_ES |
europeana.dataProvider | Universidad de Extremadura. España | es_ES |
dc.type.version | publishedVersion | es_ES |
dc.contributor.affiliation | Universidad de Extremadura. Departamento de Terapéutica Médico-Quirúrgica | es_ES |
dc.relation.publisherversion | 10.1097/FPC.0b013e328348f729 | es_ES |
dc.identifier.publicationtitle | Pharmacogenetics and Genomics | es_ES |
dc.identifier.publicationfirstpage | 565 | es_ES |
dc.identifier.publicationlastpage | 571 | es_ES |
dc.identifier.publicationvolume | 21 | es_ES |
dc.identifier.orcid | 0000-0002-9441-4022 | es_ES |
dc.identifier.orcid | 0000-0001-6895-9160 | es_ES |
Colección: | DTMQU - Artículos |
Archivos
Archivo | Descripción | Tamaño | Formato | |
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FPC_0b013e328348f729.pdf ???org.dspace.app.webui.jsptag.ItemTag.accessRestricted??? | A polymorphism located at an ATG transcription start site of the heme oxygenase-2 gene is associated with classical Parkinson’s disease | 167,16 kB | Adobe PDF | Descargar Pide una copia |
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