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http://hdl.handle.net/10662/20164
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Campo DC | Valor | idioma |
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dc.contributor.author | Mateos Quirós, Clara María | - |
dc.contributor.author | Garrido Jiménez, Sergio | - |
dc.contributor.author | Álvarez Hernán, Guadalupe | - |
dc.contributor.author | Díaz Chamorro, Selene | - |
dc.contributor.author | Barrera López, Juan Francisco | - |
dc.contributor.author | Francisco Morcillo, Javier de | - |
dc.contributor.author | Román, Ángel C | - |
dc.contributor.author | Centeno, Francisco | - |
dc.contributor.author | Carvajal González, José Maria | - |
dc.date.accessioned | 2024-02-07T09:24:30Z | - |
dc.date.available | 2024-02-07T09:24:30Z | - |
dc.date.issued | 2021 | - |
dc.identifier.uri | http://hdl.handle.net/10662/20164 | - |
dc.description.abstract | Tight-junction (TJ) proteins are essential for establishing the barrier function between neighbor epithelial cells, but also for recognition of pathogens or cell migration. Establishing the expression pattern and localization of different TJ proteins will help to understand the development and physiology of the airway. Here we identify that the junctional adhesion molecule 3 (Jam3) expression is restricted to multiciliated cells (MCCs) in the airway epithelium. In vitro, Jam3 expression varies along airway basal stem cell (BSC) differentiation and upon DAPT treatment or IL6 exposure. However, Jam3 is not required for BSC differentiation to specific cell types. In addition, we found that MCC lacking Jam3 display normal cilia morphology and cilia beating frequency with a delay in BB assembly/positioning in MCCs during differentiation. Remarkably, Jam3 in MCC is mostly localized to subapical organelles, which are negative for the apical recycling endosome marker Rab11 and positive for EEA1. Our data show that Jam3 expression is connected to mature MCC in the airway epithelium and suggest a Jam3 role unrelated to its known barrier function. | es_ES |
dc.description.sponsorship | JC-G was a recipient of a Ramón y Cajal contract (RYC- 2015-17867). This work was supported by BFU2014-54699-P and BFU2017-85547-P grants from the Ministry of Economy, IB18014 from Junta de Extremadura to JC-G, and GR15164 from Junta de Extremadura to FC. SG-J was a recipient of a Fellowship from the Universidad de Extremadura. SD-C and CM-Q were recipients of a Fellowship from Junta de Extremadura. All Spanish funding is co-sponsored by the European Union FEDER program | - |
dc.format.extent | 17 p. | es_ES |
dc.format.mimetype | application/pdf | en_US |
dc.language.iso | eng | es_ES |
dc.publisher | Francesc R. García-Gonzalo. Universidad Autónoma de Madrid | es_ES |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Células de epitelios aéreos | es_ES |
dc.subject | Airway epithelial cells | es_ES |
dc.subject | Uniones estrechas | es_ES |
dc.subject | Tight-junction | es_ES |
dc.subject | JAM3 | es_ES |
dc.subject | Células multiciliadas | es_ES |
dc.subject | Multiciliated cells | es_ES |
dc.subject | Endosomas | es_ES |
dc.subject | Endosomes | es_ES |
dc.title | Junctional adhesion molecule 3 expression in the mouse airway epithelium is linked to multiciliated cells | es_ES |
dc.type | article | es_ES |
dc.description.version | peerReviewed | es_ES |
europeana.type | TEXT | en_US |
dc.rights.accessRights | openAccess | es_ES |
dc.subject.unesco | 2415 Biología Molecular | - |
dc.subject.unesco | 2302.21 Biología Molecular | - |
dc.subject.unesco | 2401.08 Genética Animal | - |
europeana.dataProvider | Universidad de Extremadura. España | es_ES |
dc.identifier.bibliographicCitation | Mateos-Quiros CM, Garrido-Jimenez S, Álvarez-Hernán G, Diaz-Chamorro S, Barrera-Lopez JF, Francisco-Morcillo J, Roman AC, Centeno F and Carvajal-Gonzalez JM (2021) Junctional Adhesion Molecule 3 Expression in the Mouse Airway Epithelium Is Linked to Multiciliated Cells. Front. Cell Dev. Biol. 9:622515. doi: 10.3389/fcell.2021.622515 | - |
dc.type.version | acceptedVersion | es_ES |
dc.contributor.affiliation | Universidad de Extremadura. Departamento de Bioquímica, Biología Molecular y Genética | es_ES |
dc.relation.publisherversion | https://www.frontiersin.org/articles/10.3389/fcell.2021.622515/full | es_ES |
dc.identifier.doi | 10.3389/fcell.2021.622515 | - |
dc.identifier.publicationtitle | Frontiers in Cell and Developmental Biology | es_ES |
dc.identifier.publicationissue | 9 | es_ES |
dc.identifier.publicationfirstpage | 1 | es_ES |
dc.identifier.publicationlastpage | 17 | es_ES |
dc.identifier.orcid | 0000-0001-6576-830X | es_ES |
dc.identifier.orcid | 0000-0003-0941-005X | - |
dc.identifier.orcid | 0000-0001-5725-6515 | - |
dc.identifier.orcid | 0000-0002-1100-3878 | - |
dc.identifier.orcid | 0000-0001-6154-5424 | - |
Colección: | DBYBM - Artículos |
Archivos
Archivo | Descripción | Tamaño | Formato | |
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fcell_2021_622515.pdf | 4,37 MB | Adobe PDF | Descargar |
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