Identificador persistente para citar o vincular este elemento:
http://hdl.handle.net/10662/20943
Registro completo de Metadatos
Campo DC | Valor | idioma |
---|---|---|
dc.contributor.author | Delgado Adámez, Jonathan | - |
dc.contributor.author | Terrón Sánchez, María del Pilar | - |
dc.contributor.author | García Martínez, Virginio Enrique | - |
dc.contributor.author | López Sánchez, Carmen | - |
dc.contributor.author | Barriga Ibars, Carmen | - |
dc.contributor.author | Pariente Llanos, José Antonio | - |
dc.contributor.author | Rodríguez Moratinos, Ana Beatriz | - |
dc.date.accessioned | 2024-03-20T13:14:35Z | - |
dc.date.available | 2024-03-20T13:14:35Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1214-021X | - |
dc.identifier.uri | http://hdl.handle.net/10662/20943 | - |
dc.description.abstract | Recent years have seen mounting evidence for the role of melatonin in mediating programmed cell death, with a protective, anti-apoptotic effect in healthy cells, but an anti-tumoural, pro-apoptotic action in many tumour cells. In this study, we evaluated the effect of melatonin on the programmed cell death induced by thapsigargin (TG), on lymphocytes and neutrophils, and on various tissues obtained from rats injected with human promyelocytic leukæmia cells (HL-60), treated with melatonin in their drinking water (20 μm), and fed ad libitum. Melatonin treatment significantly reduced caspase-3 and −9 activity, and caused the proportions of lymphocytes, neutrophils, and eosinophils to revert to their basal values. No histological differences were observed. In conclusion, melatonin has anti-apoptotic effects on lymphocytes and neutrophils obtained from rats injected with HL-60 leukæmia cells. | es_ES |
dc.description.sponsorship | This research was supported by MEC-DGI and Junta de Extremadura grants BFU2007-60091 and PRI07-A024, respectively. | es_ES |
dc.format.extent | 11 p. | es_ES |
dc.format.mimetype | application/pdf | en_US |
dc.language.iso | eng | es_ES |
dc.publisher | University of South Bohemia | es_ES |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Melatonina | es_ES |
dc.subject | Melatonin | es_ES |
dc.subject | Neutrófilos | es_ES |
dc.subject | Linfocitos | es_ES |
dc.subject | Apoptosis | es_ES |
dc.subject | Células HL-60 | es_ES |
dc.subject | Neutrophils | es_ES |
dc.subject | Lymphocytes | es_ES |
dc.subject | HL-60 cells | es_ES |
dc.title | Oral melatonin administration and programmed cell death of neutrophils, lymphocytes, and other cell types from rats injected with HL-60 cells | es_ES |
dc.type | article | es_ES |
dc.description.version | peerReviewed | es_ES |
europeana.type | TEXT | en_US |
dc.rights.accessRights | openAccess | es_ES |
dc.subject.unesco | 2401.04 Citología Animal | es_ES |
dc.subject.unesco | 2302.15 Hormonas | es_ES |
dc.subject.unesco | 2407.04 Citología | es_ES |
europeana.dataProvider | Universidad de Extremadura. España | es_ES |
dc.identifier.bibliographicCitation | Delgado, J., del Pilar Terrón, M., García-Martinez, V., López-Sanchez, C., Barriga, C., Pariente, J.A., & Rodríguez, A.B. (2011). Oral melatonin administration and programmed cell death of neutrophils, lymphocytes, and other cell types from rats injected with HL-60 cells. Journal of Applied Biomedicine, 9(4), 197-207. doi: 10.2478/v10136-011-0006-3 | es_ES |
dc.type.version | publishedVersion | es_ES |
dc.contributor.affiliation | CICYTEX-La Orden, Área de Producción Animal | es_ES |
dc.contributor.affiliation | Universidad de Extremadura. Departamento de Anatomía, Biología Celular y Zoología | es_ES |
dc.contributor.affiliation | Universidad de Extremadura. Departamento de Fisiología | es_ES |
dc.relation.publisherversion | https://jab.zsf.jcu.cz/artkey/jab-201104-0003_oral-melatonin-administration-and-programmed-cell-death-of-neutrophils-lymphocytes-and-other-cell-types-from.php | es_ES |
dc.identifier.doi | 10.2478/v10136-011-0006-3 | - |
dc.identifier.publicationtitle | Journal of Applied Biomedicine | es_ES |
dc.identifier.publicationissue | 4 | es_ES |
dc.identifier.publicationfirstpage | 197 | es_ES |
dc.identifier.publicationlastpage | 207 | es_ES |
dc.identifier.publicationvolume | 9 | es_ES |
dc.identifier.e-issn | 1214-0287 | - |
dc.identifier.orcid | 0000-0002-7760-1985 | es_ES |
dc.identifier.orcid | 0000-0003-3296-2071 | es_ES |
Colección: | DABCZ - Artículos DFSIO - Artículos |
Archivos
Archivo | Descripción | Tamaño | Formato | |
---|---|---|---|---|
v10136-011-0006-3.pdf | 3,28 MB | Adobe PDF | Descargar |
Este elemento está sujeto a una licencia Licencia Creative Commons