Lack of association of vitamin D receptor BsmI gene polymorphism with bone mineral density in Spanish postmenopausal women

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Lack of association of vitamin D receptor BsmI gene polymorphism with bone mineral density in Spanish postmenopausal women

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Title: Lack of association of vitamin D receptor BsmI gene polymorphism with bone mineral density in Spanish postmenopausal women
Author: Morán García, José María; Pedrera Canal, María; Rodríguez Velasco, Francisco José; Vera González, Vicente; Lavado García, Jesús María; Fernández Fernández, Pilar; Pedrera Zamorano, Juan Diego
Abstract: La osteoporosis es un trastorno poligénico que está determinada por los efectos de varios genes, cada uno con efectos relativamente modestos en la masa ósea. El objetivo de este estudio es determinar si el receptor de la vitamina D, único nucleótido polimorfismo BsmI, está asociado con la densidad mineral ósea (DMO) de mujeres posmenopáusicas españolas. Un total de 210 mujeres posmenopáusicas sanas, mayores de 60 ± 8 años, fueron genotipificadas utilizando ensayos de genotipado SNP TaqMan® lumbar y la DMO femoral; y se determinó por la absorciometría de rayos X de energía dual (DEXA) la cantidad diaria de calcio y vitamina D. No se encontraron diferencias en el cuello femoral, trocánter, triángulo de salas, L2, L3, L4, L2-L4, o entre el cuello femoral y la DMO de cadera total tras el ajuste para posibles factores de confusión (P > 0,05) (edad, IMC, años después de la menopausia y la ingesta diaria de calcio). La BsmI polimorfismo en el gen VDR no se asoció con la DMO en mujeres posmenopáusicas españolas.Osteoporosis is a polygenic disorder that is determined by the effects of several genes, each with relatively modest effects on bone mass. The aim of this study was to determine whether the vitamin D receptor single nucleotide polymorphism BsmI is associated with bone mineral density (BMD) in Spanish postmenopausal women. A total of 210 unrelated healthy postmenopausal women aged 60 ± 8 years were genotyped using TaqManR SNP Genotyping Assays. Lumbar and femoral BMD were determined by dual-energy X-ray absorptiometry (DEXA). Daily calcium and vitamin D intake were determined by a food questionnaire. No differences were found in the femoral neck, trochanter, Ward’s Triangle, L2, L3, L4, L2-L4, or between the femoral neck and total hip BMD after further adjustment for potential confounding factors (P > 0.05) (age, BMI, years since menopause and daily calcium intake). The BsmI polymorphism in the VDR gene was not associated with BMD in Spanish postmenopausal women.
URI: http://hdl.handle.net/10662/5650
Date: 2015


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Atribución-NoComercial-CompartirIgual 3.0 España Except where otherwise noted, this item's license is described as Atribución-NoComercial-CompartirIgual 3.0 España

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