Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10662/6922
Títulos: Positioning of centrioles is a conserved readout of Frizzled planar cell polarity signalling
Autores/as: Carvajal González, José María
Román García, Ángel Carlos
Mlodzik, Marek
Palabras clave: Polaridad cellular plana;Orientación celular;Drosophila;Planar cell polarity;Cellular orientation
Fecha de publicación: 2016
Editor/a: Natural Publishing Group
Resumen: Planar cell polarity (PCP) signalling is a well-conserved developmental pathway regulating cellular orientation during development. An evolutionarily conserved pathway readout is not established and, moreover, it is thought that PCP mediated cellular responses are tissue-specific. A key PCP function in vertebrates is to regulate coordinated centriole/cilia positioning, a function that has not been associated with PCP in Drosophila. Here we report instructive input of Frizzled-PCP (Fz/PCP) signalling into polarized centriole positioning in Drosophila wings. We show that centrioles are polarized in pupal wing cells as a readout of PCP signalling, with both gain and loss-of-function Fz/PCP signalling affecting centriole polarization. Importantly, loss or gain of centrioles does not affect Fz/PCP establishment, implicating centriolar positioning as a conserved PCP-readout, likely downstream of PCP-regulated actin polymerization. Together with vertebrate data, these results suggest a unifying model of centriole/cilia positioning as a common downstream effect of PCP signalling from flies to mammals.
URI: http://hdl.handle.net/10662/6922
ISSN: 2041-1723
DOI: 10.1038/ncomms11135
Colección:DBYBM - Artículos

Archivos
Archivo Descripción TamañoFormato 
ncomms11135.pdf3,2 MBAdobe PDFDescargar


Este elemento está sujeto a una licencia Licencia Creative Commons Creative Commons