Positioning of centrioles is a conserved readout of Frizzled planar cell polarity signalling

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Positioning of centrioles is a conserved readout of Frizzled planar cell polarity signalling

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Título: Positioning of centrioles is a conserved readout of Frizzled planar cell polarity signalling
Autor: Carvajal Gonzalez, José María; Román García, Ángel Carlos; Mlodzik, Marek
Resumen: Planar cell polarity (PCP) signalling is a well-conserved developmental pathway regulating cellular orientation during development. An evolutionarily conserved pathway readout is not established and, moreover, it is thought that PCP mediated cellular responses are tissue-specific. A key PCP function in vertebrates is to regulate coordinated centriole/cilia positioning, a function that has not been associated with PCP in Drosophila. Here we report instructive input of Frizzled-PCP (Fz/PCP) signalling into polarized centriole positioning in Drosophila wings. We show that centrioles are polarized in pupal wing cells as a readout of PCP signalling, with both gain and loss-of-function Fz/PCP signalling affecting centriole polarization. Importantly, loss or gain of centrioles does not affect Fz/PCP establishment, implicating centriolar positioning as a conserved PCP-readout, likely downstream of PCP-regulated actin polymerization. Together with vertebrate data, these results suggest a unifying model of centriole/cilia positioning as a common downstream effect of PCP signalling from flies to mammals.
URI: http://hdl.handle.net/10662/6922
Fecha: 2016


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