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http://hdl.handle.net/10662/6922
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Campo DC | Valor | idioma |
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dc.contributor.author | Carvajal González, José María | - |
dc.contributor.author | Román García, Ángel Carlos | - |
dc.contributor.author | Mlodzik, Marek | - |
dc.date.accessioned | 2018-02-02T12:57:14Z | - |
dc.date.available | 2018-02-02T12:57:14Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | http://hdl.handle.net/10662/6922 | - |
dc.description.abstract | Planar cell polarity (PCP) signalling is a well-conserved developmental pathway regulating cellular orientation during development. An evolutionarily conserved pathway readout is not established and, moreover, it is thought that PCP mediated cellular responses are tissue-specific. A key PCP function in vertebrates is to regulate coordinated centriole/cilia positioning, a function that has not been associated with PCP in Drosophila. Here we report instructive input of Frizzled-PCP (Fz/PCP) signalling into polarized centriole positioning in Drosophila wings. We show that centrioles are polarized in pupal wing cells as a readout of PCP signalling, with both gain and loss-of-function Fz/PCP signalling affecting centriole polarization. Importantly, loss or gain of centrioles does not affect Fz/PCP establishment, implicating centriolar positioning as a conserved PCP-readout, likely downstream of PCP-regulated actin polymerization. Together with vertebrate data, these results suggest a unifying model of centriole/cilia positioning as a common downstream effect of PCP signalling from flies to mammals. | es_ES |
dc.description.sponsorship | Trabajo financiado por: Gobierno de Extremadura. Ayuda para la Atracción y Retención de Talento Investigador, para José María Carvajal González | es_ES |
dc.format.extent | 9 p. | es_ES |
dc.format.mimetype | application/pdf | en_US |
dc.language.iso | eng | es_ES |
dc.publisher | Natural Publishing Group | es_ES |
dc.rights | Atribución-NoComercial-SinDerivadas 3.0 España | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.subject | Polaridad cellular plana | es_ES |
dc.subject | Orientación celular | es_ES |
dc.subject | Drosophila | es_ES |
dc.subject | Planar cell polarity | es_ES |
dc.subject | Cellular orientation | es_ES |
dc.title | Positioning of centrioles is a conserved readout of Frizzled planar cell polarity signalling | es_ES |
dc.type | article | es_ES |
dc.description.version | peerReviewed | es_ES |
europeana.type | TEXT | en_US |
dc.rights.accessRights | openAccess | es_ES |
dc.subject.unesco | 2407 Biología Celular | es_ES |
europeana.dataProvider | Universidad de Extremadura. España | es_ES |
dc.identifier.bibliographicCitation | Carvajal Gonzalez, J. M.; Román García, A C. y Mlodzik, M. (2016). Positioning of centrioles is a conserved readout of Frizzled planar cell polarity signalling. Nature communications, 7, 11135. ESSN 2041-1723 | es_ES |
dc.type.version | publishedVersion | es_ES |
dc.contributor.affiliation | Universidad de Extremadura. Departamento de Bioquímica, Biología Molecular y Genética | es_ES |
dc.relation.publisherversion | https://www.nature.com/articles/ncomms11135 | es_ES |
dc.identifier.doi | 10.1038/ncomms11135 | - |
dc.identifier.publicationtitle | Nature communications | es_ES |
dc.identifier.publicationfirstpage | 1 | es_ES |
dc.identifier.publicationlastpage | 9 | es_ES |
dc.identifier.publicationvolume | 7, 11135 | es_ES |
Colección: | DBYBM - Artículos |
Archivos
Archivo | Descripción | Tamaño | Formato | |
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ncomms11135.pdf | 3,2 MB | Adobe PDF | Descargar |
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