Positioning of centrioles is a conserved readout of Frizzled planar cell polarity signalling

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Positioning of centrioles is a conserved readout of Frizzled planar cell polarity signalling

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dc.contributor.author Carvajal González, José María
dc.contributor.author Román García, Ángel Carlos
dc.contributor.author Mlodzik, Marek
dc.date.accessioned 2018-02-02T12:57:14Z
dc.date.available 2018-02-02T12:57:14Z
dc.date.issued 2016
dc.identifier.issn 2041-1723
dc.identifier.uri http://hdl.handle.net/10662/6922
dc.description.abstract Planar cell polarity (PCP) signalling is a well-conserved developmental pathway regulating cellular orientation during development. An evolutionarily conserved pathway readout is not established and, moreover, it is thought that PCP mediated cellular responses are tissue-specific. A key PCP function in vertebrates is to regulate coordinated centriole/cilia positioning, a function that has not been associated with PCP in Drosophila. Here we report instructive input of Frizzled-PCP (Fz/PCP) signalling into polarized centriole positioning in Drosophila wings. We show that centrioles are polarized in pupal wing cells as a readout of PCP signalling, with both gain and loss-of-function Fz/PCP signalling affecting centriole polarization. Importantly, loss or gain of centrioles does not affect Fz/PCP establishment, implicating centriolar positioning as a conserved PCP-readout, likely downstream of PCP-regulated actin polymerization. Together with vertebrate data, these results suggest a unifying model of centriole/cilia positioning as a common downstream effect of PCP signalling from flies to mammals. es_ES
dc.description.sponsorship Trabajo financiado por: Gobierno de Extremadura. Ayuda para la Atracción y Retención de Talento Investigador, para José María Carvajal González es_ES
dc.format.extent 9 p. es_ES
dc.format.mimetype application/pdf en_US
dc.language.iso eng es_ES
dc.publisher Natural Publishing Group es_ES
dc.rights Atribución-NoComercial-SinDerivadas 3.0 España *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/es/ *
dc.subject Polaridad cellular plana es_ES
dc.subject Orientación celular es_ES
dc.subject Drosophila es_ES
dc.subject Planar cell polarity es_ES
dc.subject Cellular orientation es_ES
dc.title Positioning of centrioles is a conserved readout of Frizzled planar cell polarity signalling es_ES
dc.type article es_ES
dc.description.version peerReviewed es_ES
europeana.type TEXT en_US
dc.rights.accessRights openAccess es_ES
dc.subject.unesco 2407 Biología Celular es_ES
europeana.dataProvider Universidad de Extremadura. España es_ES
dc.identifier.bibliographicCitation Carvajal Gonzalez, J. M.; Román García, A C. y Mlodzik, M. (2016). Positioning of centrioles is a conserved readout of Frizzled planar cell polarity signalling. Nature communications, 7, 11135. ESSN 2041-1723 es_ES
dc.type.version publishedVersion es_ES
dc.contributor.affiliation Universidad de Extremadura. Departamento de Bioquímica, Biología Molecular y Genética es_ES
dc.relation.publisherversion https://www.nature.com/articles/ncomms11135 es_ES
dc.identifier.doi 10.1038/ncomms11135
dc.identifier.publicationtitle Nature communications es_ES
dc.identifier.publicationfirstpage 1 es_ES
dc.identifier.publicationlastpage 9 es_ES
dc.identifier.publicationvolume 7, 11135 es_ES

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