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http://hdl.handle.net/10662/7188
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Campo DC | Valor | idioma |
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dc.contributor.author | Mateos Muñoz, Beatriz | - |
dc.contributor.author | García Martín, Elena | - |
dc.contributor.author | Torrejón Rueda, María José | - |
dc.contributor.author | Devesa Medina, María José | - |
dc.contributor.author | Esguevillas Cansino, Gara | - |
dc.contributor.author | Cárdenas Fernández, María Cruz | - |
dc.contributor.author | Fernández Pérez, Cristina | - |
dc.contributor.author | Carballo Villarino, Miguel | - |
dc.contributor.author | García-Agúndez Pérez-Coca, José Augusto | - |
dc.contributor.author | Ladero Quesada, José María | - |
dc.date.accessioned | 2018-03-16T11:34:44Z | - |
dc.date.available | 2018-03-16T11:34:44Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0025-7974 | - |
dc.identifier.uri | http://hdl.handle.net/10662/7188 | - |
dc.description.abstract | Insulin resistance (IR) is found in chronic hepatitis C (CHC) more frequently than in other chronic liver diseases. Prospective cross-sectional study to evaluate a wide multitest panel to identify factors related with IR in CHC and their possible interactions. In 76 patients with CHC we performed a series of routine laboratory analysis as well as specifically designed serum biochemical tests [retinol, retinol-binding protein 4 (RBP4), 25-OH vitamin D, Vitamin E, lipopolysaccharide-binding protein (LBP), interleukin-6 (IL-6), and cystatin C]. The single nucleotide polymorphisms rs7041 and rs4588 GC-DBP (group-specific component-Vitamin D-binding protein), rs738409 PNPLA3 (patatin-like phospholipase domain containing 3), and rs12979860 IL28B (interleukin-28 B) genes were determined. Insulin sensitivity was established with the HOMA-IR and IR was diagnosed when HOMA-IR>3. Fibrosis staging was assessed with liver biopsy or transient elastography. After backward logistic regression analysis, independent variables associated with IR were Gc1s/Gc1s DBP phenotype, that results from the homozygous carriage of the rs7041G/rs4588Chaplotype (P¼0.033); low retinol/RBP4 ratio, reflecting a greater rate of unboundRBP4 (P¼0.005); older age (P¼0.01); high serum tryglicerides (P¼0.026); and advanced (F3–F4) fibrosis stage. The AUROC provided by the multivariate model was 0.950 (95% CI¼0.906–0.993). In addition to previously known ones, the Gc1s/Gc1s phenotype variant of DBP and the unbound fraction of plasma RBP4 may be considered as factors related with the incidence, and possibly the risk, of IR in CHC patients. | es_ES |
dc.description.sponsorship | • Instituto de Salud Carlos III, Fondo de Investigación Sanitari: Ayudas PI12/00241 y PI12/00324 • Junta de Extremadura: Ayuda GR15026 • Fondos FEDER | es_ES |
dc.format.extent | 6 p. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Wolters Kluwer Health | es_ES |
dc.rights | Atribución-NoComercial-SinDerivadas 3.0 España | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.subject | Polimorfismo | es_ES |
dc.subject | Proteina 4 | es_ES |
dc.subject | Insulina | es_ES |
dc.subject | Hepatitis C | es_ES |
dc.subject | Polymosphirm | es_ES |
dc.subject | Protein 4 | es_ES |
dc.subject | Insulin | es_ES |
dc.title | GC gene polymorphism and unbound serum retinol-binding protein 4 are related to the risk of insulin resistance in patients with chronic hepatitis c: A prospective cross-sectional study | es_ES |
dc.type | article | es_ES |
dc.description.version | peerReviewed | es_ES |
dc.rights.accessRights | openAccess | es_ES |
dc.subject.unesco | 2302.27 Proteínas | es_ES |
dc.identifier.bibliographicCitation | Mateos Muñoz, B.; García Martín, E.; Torrejón Rueda, M. J.; Devesa Medina, M. J.; Esguevillas Cansino, G.; Cárdenas Fernández, M. C. y Fernández Pérez, C. [et al.]. (2016). GC gene polymorphism and unbound serum retinol-binding protein 4 are related to the risk of insulin resistance in patients with chronic hepatitis c: A prospective cross-sectional study. Medicine, 95, 10, e3019. ESSN 1536-5964 | es_ES |
dc.type.version | publishedVersion | es_ES |
dc.contributor.affiliation | Hospital Clínico San Carlos. Madrid | es_ES |
dc.contributor.affiliation | Universidad de Extremadura. Departamento de Terapéutica Médico-Quirúrgica | es_ES |
dc.contributor.affiliation | Hospital de Terrassa (Terrassa, Barcelona) | es_ES |
dc.contributor.affiliation | Universidad Complutense de Madrid | es_ES |
dc.relation.publisherversion | https://journals.lww.com/md-journal/Fulltext/2016/03080/GC_Gene_Polymorphism_and_Unbound_Serum.56.aspx | es_ES |
dc.identifier.doi | 10.1097/MD.0000000000003019 | - |
dc.identifier.publicationtitle | Medicine | es_ES |
dc.identifier.publicationissue | 10 | es_ES |
dc.identifier.publicationfirstpage | 1 | es_ES |
dc.identifier.publicationlastpage | 6 | es_ES |
dc.identifier.publicationvolume | 95, e3019 | es_ES |
Colección: | DTMQU - Artículos |
Archivos
Archivo | Descripción | Tamaño | Formato | |
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MD_0000000000003019.pdf | 250,09 kB | Adobe PDF | Descargar |
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