An easy synthesis of diversely functionalized 2H-chromenes and amido amines by an enol-Ugi reaction

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An easy synthesis of diversely functionalized 2H-chromenes and amido amines by an enol-Ugi reaction

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Title: An easy synthesis of diversely functionalized 2H-chromenes and amido amines by an enol-Ugi reaction
Author: Gómez Neo, Ana María; González Castellano, María Teresa; Fernández Marcos, Carlos María
Abstract: The first synthesis of methyl 2-(4-hydroxy-2-oxo-2H-chromen-3-yl)-2-oxoacetate is described. This compound has been successfully used in a multicomponent enol-Ugi condensation with imines and isocyanides affording 4-aminoacyl-coumarin enamines in a highly atom-economic and convergent process. Furthermore, the postcondensation transformation of these adducts allows the straightforward synthesis of both unprotected amino amides and as yet unknown 2-hydroxychromenyl enamines.
URI: http://hdl.handle.net/10662/7272
Date: 2016


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