A nonsynonymous FCER1B SNP is associated with risk of developing allergic rhinitis and with IgE levels

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A nonsynonymous FCER1B SNP is associated with risk of developing allergic rhinitis and with IgE levels

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dc.contributor.author Amo Marín, Gemma
dc.contributor.author García Menaya, Jesús Miguel
dc.contributor.author Campo Mozo, Paloma
dc.contributor.author Cordobés Durán, Concepción
dc.contributor.author Plaza Serón, María Carmen
dc.contributor.author Ayuso Parejo, Pedro
dc.contributor.author Esguevillas Cansino, Gara
dc.contributor.author Blanca Gómez, Miguel
dc.contributor.author García-Agúndez Pérez-Coca, José Augusto
dc.contributor.author García Martín, María Elena
dc.date.accessioned 2018-05-09T12:19:43Z
dc.date.available 2018-05-09T12:19:43Z
dc.date.issued 2016
dc.identifier.issn 2045-2322
dc.identifier.uri http://hdl.handle.net/10662/7403
dc.description.abstract Allergic rhinitis is associated with elevated serum IgE levels. IgE response is mediated by the highaffinity IgE receptor (FcεRI), which is polymorphic. Studies analyzing the association between allergic rhinitis and FcεRI variants have been conducted with controversial results. The objective of this study is to analyze, in 1,041 individuals, the putative clinical association of allergic rhinitis with common polymorphisms in FcεRI subunits genes. These SNPs included FECR1A rs2494262, rs2427837 and rs2251746; FECR1B rs1441586, rs569108 and rs512555; FCER1G rs11587213, rs2070901 and rs11421. Statistically significant differences were observed for the FCER1B rs569108 and rs512555 polymorphisms frequencies when comparing patients with allergic rhinitis without asthma and controls. The OR (95% CI) value for the 237Gly allele (rs569108) is equal to 0.26 (0.08–0.86, P = 0.017) and for the G allele (rs512555) it is equal to 0.27 (0.08–0.88, P = 0.020). These two SNPs are linked (D’ = 1.0, LOD = 56.05). Also observed was a statistically significant trend towards lower IgE values among allergic rhinitis patients with variant alleles for both SNPs. In conclusion, in patients with allergic rhinitis without asthma, the FCER1B rs569108 and rs512555 polymorphisms are associated with increased risk of developing allergic rhinitis and with lower IgE levels. es_ES
dc.description.sponsorship Trabajo financiado por: Instituto de Salud Carlos III. Fondo de Investigación Sanitaria. Becas PI12/00241, PI12/00324 y RETICS RD12/0013/0002 Junta de Extremadura y Fondos FEDER. Ayuda GR15026 es_ES
dc.format.extent 7 p. es_ES
dc.language.iso eng es_ES
dc.publisher Nature Publishing Group es_ES
dc.rights Atribución-NoComercial-SinDerivadas 3.0 España *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/es/ *
dc.subject Rinitis alérgica es_ES
dc.subject Niveles de IgE en suero es_ES
dc.subject Asma es_ES
dc.subject Allergic rhinitis es_ES
dc.subject Serum IgE levels es_ES
dc.subject Asthma es_ES
dc.title A nonsynonymous FCER1B SNP is associated with risk of developing allergic rhinitis and with IgE levels es_ES
dc.type article es_ES
dc.description.version peerReviewed es_ES
dc.rights.accessRights openAccess es_ES
dc.subject.unesco 3207.01 Alergias es_ES
dc.subject.unesco 3205.08 Enfermedades Pulmonares es_ES
dc.identifier.bibliographicCitation Amo Marín, G.; García Menaya, J. M.; Campo Mozo, P. ; Cordobés Durán, C.; Plaza Serón, M. C.; Ayuso Parejo, P.; Esguevillas Cansino, G. [et al.]. (2016). A nonsynonymous FCER1B SNP is associated with risk of developing allergic rhinitis and with IgE levels. Scientific reports, 6, 19724. ESSN 2045-2322 es_ES
dc.type.version publishedVersion es_ES
dc.contributor.affiliation Hospital Universitario Infanta Cristina. Badajoz es_ES
dc.contributor.affiliation Universidad de Extremadura. Departamento de Terapéutica Médico-Quirúrgica es_ES
dc.contributor.affiliation Hospital Regional Universitario Carlos Haya. Málaga
dc.contributor.affiliation Hospital Universitario Virgen de la Victoria. Málaga
dc.relation.publisherversion https://www.nature.com/articles/srep19724 es_ES
dc.identifier.doi 10.1038/srep19724
dc.identifier.publicationtitle Scientific reports es_ES
dc.identifier.publicationfirstpage 1 es_ES
dc.identifier.publicationlastpage 7 es_ES
dc.identifier.publicationvolume 6, 19724 es_ES

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