Soluble fractalkine in the plasma of fibromyalgia patients

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Soluble fractalkine in the plasma of fibromyalgia patients

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Title: Soluble fractalkine in the plasma of fibromyalgia patients
Author: García García, Juan José; Ortega Rincón, Eduardo
Abstract: La fibromialgia es una forma de reumatismo no articular en el que parecen estar implicadas las citocinas inflamatorias. Sin embargo, todavía no existe ningún criterio diagnóstico analítico específico para esta enfermedad. El objetivo fue examinar un posible papel de fractalkine como un biomarcador en la fibromialgia. Los niveles plasmáticos de fractalina soluble se compararon entre mujeres diagnosticadas con fibromialgia (n = 17) y mujeres sanas (n = 10) como controles. También se evaluó la fractalina liberada por monocitos. Los pacientes con fibromialgia mostraron menor fractalina plasmática que las mujeres sanas. Dado que la mayoría de las patologías inflamatorias muestran niveles plasmáticos elevados de fractalina soluble, los resultados pueden contribuir a un diagnóstico diferencial de la fibromialgia.Fibromyalgia is a form of non-articular rheumatism in which inflammatory cytokines seem to be involved. However, there is still no analytical specific diagnostic criterion for this disease. The aim was to examine a possible role of fractalkine as a biomarker in fibromyalgia. Plasma levels of soluble fractalkine were compared between women diagnosed with fibromyalgia (n=17) and healthy women (n=10) as controls. Fractalkine released by monocytes was also evaluated. Fibromyalgia patients showed lower plasma fractalkine than healthy women. Since most inflammatory pathologies show elevated plasma levels of soluble fractalkine, the results may contribute towards a differential diagnosis for fibromyalgia.
URI: http://hdl.handle.net/10662/7762
Date: 2014


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