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http://hdl.handle.net/10662/13562
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Campo DC | Valor | idioma |
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dc.contributor.author | Peña Vega, Fernando Juan | - |
dc.contributor.author | Ortiz Rodríguez, José Manuel | - |
dc.contributor.author | Gaitskell Phillips, Gemma | - |
dc.contributor.author | Gil Anaya, María Cruz | - |
dc.contributor.author | Ortega Ferrusola, Cristina | - |
dc.contributor.author | Martín Cano, Francisco Eduardo | - |
dc.date.accessioned | 2022-02-02T11:05:27Z | - |
dc.date.available | 2022-02-02T11:05:27Z | - |
dc.date.issued | 2021 | - |
dc.identifier.uri | http://hdl.handle.net/10662/13562 | - |
dc.description.abstract | An overview of the sperm metabolism is presented; using the stallion as a model we review glycolysis, Krebs Cycle and oxidative phosphorylation, paying special attention to the interactions among them. In addition, metabolism implies a series of coordinated oxidation-reduction reactions and in the course of these reactions reactive oxygen species (ROS) and reactive oxoal-dehydes are produced ; the electron transport chain (ETC) in the mitochondria is the main source of the anion superoxide and hydrogen peroxide, while glycolysis produces 2-oxoaldehydes such as methylglyoxal as byproducts; due to the adjacent carbonyl groups are strong electrophiles (steal electrons oxidizing other compounds). Sophisticated mechanisms exist to maintain redox homeostasis, because ROS under controlled production also have important regulatory functions in the spermatozoa. The interactions between metabolism and production of reactive oxygen species are essential for proper sperm function, and deregulation of these processes rapidly leads to sperm malfunction and finally death. Lastly, we briefly describe two techniques that will expand our knowledge on sperm metabolism in the coming decades, metabolic flow cytometry and the use of the “omics” technologies, proteomics and metabolomics, specifically the micro and nano proteomics/metabolomics. A better understanding of the metabolism of the spermatozoa will lead to big improvements in sperm technologies and the diagnosis and treatment of male factor infertility. | es_ES |
dc.format.extent | 12 p. | es_ES |
dc.format.mimetype | application/pdf | en_US |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Spermatozoa | es_ES |
dc.subject | Methylglyoxal | es_ES |
dc.subject | Reactive oxygen species (ROS) | es_ES |
dc.subject | Metabolism | es_ES |
dc.subject | Equine | es_ES |
dc.subject | Equino | es_ES |
dc.subject | Espermatozoide | es_ES |
dc.subject | Especies de oxígeno reactivas | es_ES |
dc.subject | Metabolismo | es_ES |
dc.subject | Metilglioxal | es_ES |
dc.title | An integrated overview on the regulation of sperm metabolism (glycolysis-Krebs cycle-oxidative phosphorylation) | es_ES |
dc.type | article | es_ES |
dc.description.version | Peer Reviewed | - |
europeana.type | TEXT | en_US |
dc.rights.accessRights | openAccess | es_ES |
dc.subject.unesco | 3104.05 Équidos | es_ES |
dc.subject.unesco | 3104.11 Reproducción | es_ES |
dc.subject.unesco | 3206.02 Metabolismo Energético | es_ES |
europeana.dataProvider | Universidad de Extremadura. España | es_ES |
dc.identifier.bibliographicCitation | Peña Vega, F.J., Ortíz Rodríguez, J.M., Gaitskell Phillips, G., Gil Anaya, M.C., Ortega Ferrusola, C. & Martín Cano, F.E. (2021). An integrated overview on the regulation of sperm metabolism (glycolysis-Krebs cycle-oxidative phosphorylation). Animal Reproduction Science, 106805. https://doi.org/10.1016/j.anireprosci.2021.106805 | es_ES |
dc.type.version | AcceptedVersión | es_ES |
dc.contributor.affiliation | Universidad de Extremadura. Departamento de Medicina Animal | es_ES |
dc.contributor.affiliation | Universidad de Extremadura. Hospital Clínico Veterinario | - |
dc.identifier.doi | 10.1016/j.anireprosci.2021.106805 | - |
dc.identifier.publicationtitle | Animal Reproduction Science | es_ES |
dc.identifier.publicationfirstpage | 106805-1 | es_ES |
dc.identifier.publicationlastpage | 106805-12 | es_ES |
dc.identifier.e-issn | 0378-4320 | - |
dc.identifier.orcid | 0000-0002-1311-2947 | - |
dc.identifier.orcid | 0000-0002-3248-6493 | - |
Colección: | DMANI - Artículos |
Archivos
Archivo | Descripción | Tamaño | Formato | |
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j.anireprosci.2021.106805.pdf | 2,84 MB | Adobe PDF | Descargar |
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