Identificador persistente para citar o vincular este elemento:
http://hdl.handle.net/10662/19899
Registro completo de Metadatos
Campo DC | Valor | idioma |
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dc.contributor.author | Camello Almaraz, María Cristina | - |
dc.contributor.author | Martín Cano, Francisco Eduardo | - |
dc.contributor.author | Santos Garzón, Francisco Javier | - |
dc.contributor.author | Espín Jaime, María Teresa | - |
dc.contributor.author | Madrid Pérez, Juan Antonio | - |
dc.contributor.author | Pozo Andrada, María José | - |
dc.contributor.author | Camello Almaraz, Pedro Javier | - |
dc.date.accessioned | 2024-02-05T11:31:32Z | - |
dc.date.available | 2024-02-05T11:31:32Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 1661-6596 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10662/19899 | - |
dc.description.abstract | Aging modifies not only multiple cellular and homeostatic systems, but also biological rhythms. The circadian system is driven by a central hypothalamic oscillator which entrains peripheral oscillators, in both cases underlain by circadian genes. Our aim was to characterize the effect of aging in the circadian expression of clock genes in the human colon. Ambulatory recordings of the circadian rhythms of skin wrist temperature, motor activity and the integrated variable TAP (temperature, activity and position) were dampened by aging, especially beyond 74 years of age. On the contrary, quantitative analysis of genes expression in the muscle layer of colonic explants during 24 h revealed that the circadian expression of Bmal1, Per1 and Clock genes, was larger beyond that age. In vitro experiments showed that aging induced a parallel increase in the myogenic contractility of the circular colonic muscle. This effect was not accompanied by enhancement of Ca2+ signals. In conclusion, we describe here for the first time the presence of a molecular oscillator in the human colon. Aging has a differential effect on the systemic circadian rhythms, that are impaired by aging, and the colonic oscillator, that is strengthened in parallel with the myogenic contractility. | es_ES |
dc.description.sponsorship | Funded by grant from Spanish Ministerio de Ciencia e Innovación (BFU2011-24365) and by FEDER and Junta de Extremadura (GR18119 and IB18025) awarded to MJ Pozo. | eng_US |
dc.format.extent | 13 p. | es_ES |
dc.format.mimetype | application/pdf | en_US |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | Attribution 4.0 International | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.subject | Circadian rhythms | es_ES |
dc.subject | Smooth muscle | es_ES |
dc.subject | Clock genes | es_ES |
dc.subject | Colon | es_ES |
dc.subject | Contractilidad | es_ES |
dc.subject | Señales de calcio | es_ES |
dc.subject | Contractility | eng_US |
dc.subject | Calcium signals | eng_US |
dc.subject | Ritmos circadianos | es_ES |
dc.subject | Músculo liso | es_ES |
dc.subject | Genes reloj | es_ES |
dc.title | Age-Induced Differential Changes in the Central and Colonic Human Circadian Oscillators | es_ES |
dc.type | article | es_ES |
dc.description.version | peerReviewed | es_ES |
europeana.type | TEXT | en_US |
dc.rights.accessRights | openAccess | es_ES |
dc.subject.unesco | 6108.02 Madurez | es_ES |
dc.subject.unesco | 2411 Fisiología Humana | es_ES |
europeana.dataProvider | Universidad de Extremadura. España | es_ES |
dc.identifier.bibliographicCitation | Camello-Almaraz, C.; Martin-Cano, F.E.; Santos, F.J.; Espin, M.T.; Antonio Madrid, J.; Pozo, M.J.; Camello, P.J. Age-Induced Differential Changes in the Central and Colonic Human Circadian Oscillators. Int. J. Mol. Sci. 2020, 21, 674. https://doi.org/10.3390/ijms21020674 | es_ES |
dc.type.version | publishedVersion | es_ES |
dc.contributor.affiliation | Universidad de Extremadura. Departamento de Fisiología | es_ES |
dc.contributor.affiliation | Hospital Universitario (Cáceres). Departamento de Cirugía | es_ES |
dc.contributor.affiliation | Universidad de Extremadura. Instituto de Patología Molecular Biomarcadores | es_ES |
dc.contributor.affiliation | Hospital Universitario de Badajoz | es_ES |
dc.contributor.affiliation | Universidad de Murcia. Departamento de Fisiología | es_ES |
dc.relation.publisherversion | https://www.mdpi.com/1422-0067/21/2/674 | es_ES |
dc.relation.publisherversion | https://doi.org/10.3390/ijms21020674 | es_ES |
dc.identifier.doi | 10.3390/ijms21020674 | - |
dc.identifier.publicationtitle | International Journal of Molecular Sciences | es_ES |
dc.identifier.publicationissue | 21 | es_ES |
dc.identifier.publicationfirstpage | 674 | es_ES |
dc.identifier.publicationlastpage | 687 | es_ES |
dc.identifier.e-issn | 1422-0067 | es_ES |
dc.identifier.orcid | 0000-0003-0882-8497 | es_ES |
dc.identifier.orcid | 0000-0001-5026-7166 | es_ES |
dc.identifier.orcid | 0000-0003-4971-4883 | es_ES |
dc.identifier.orcid | 0000-0002-4137-6798 | es_ES |
Colección: | DFSIO - Artículos |
Archivos
Archivo | Descripción | Tamaño | Formato | |
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ijms21020674.pdf | 1,38 MB | Adobe PDF | Descargar |
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