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http://hdl.handle.net/10662/19930
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Campo DC | Valor | idioma |
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dc.contributor.author | Blázquez Durán, Rebeca | - |
dc.contributor.author | Álvarez Pérez, Verónica | - |
dc.contributor.author | Antequera Barroso, Juan Antonio | - |
dc.contributor.author | Báez Díaz, Claudia | - |
dc.contributor.author | Blanco Blázquez, Virginia | - |
dc.contributor.author | Maestre, Juan | - |
dc.contributor.author | Moreno Lobato, Beatriz | - |
dc.contributor.author | López, Esther | - |
dc.contributor.author | Marinaro, Federica | - |
dc.contributor.author | García Casado, Javier | - |
dc.contributor.author | Crisóstomo Ayala, Verónica | - |
dc.contributor.author | Sánchez Margallo, Francisco Miguel | - |
dc.date.accessioned | 2024-02-05T12:46:32Z | - |
dc.date.available | 2024-02-05T12:46:32Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0165-2427 | - |
dc.identifier.uri | http://hdl.handle.net/10662/19930 | - |
dc.description.abstract | Preclinical studies in cardiovascular medicine are necessary to translate basic research to the clinic. The porcine model has been widely used to understand the biological mechanisms involved in cardiovascular disorders for which purpose different closed-chest models have been developed in the last years to mimic the pathophysiological events seen in human myocardial infarction. In this work, we studied hematological, biochemical and immunological parameters, as well as Magnetic resonance derived cardiac function measurements obtained from a swine myocardial infarction model. We identified some blood parameters which were significantly altered after myocardial infarction induction. More importantly, these parameters (gamma-glutamyl transferase, glutamic pyruvic transaminase, red blood cell counts, hemoglobin concentration, hematocrit, platelet count and plateletcrit) correlated positively with cardiac function, infarct size and/or cardiac enzymes (troponin I and creatine kinase-MB). Thus several blood-derived parameters have allowed us to predict the severity of myocardial infarction in a clinically relevant animal model. Therefore, here we provide a simple, affordable and reliable way that could prove useful in the follow up of myocardial infarction and in the evaluation of new therapeutic strategies in this animal model. | es_ES |
dc.description.abstract | Preclinical studies in cardiovascular medicine are necessary to translate basic research to the clinic. The porcine model has been widely used to understand the biological mechanisms involved in cardiovascular disorders for which purpose different closed-chest models have been developed in the last years to mimic the pathophysiological events seen in human myocardial infarction. In this work, we studied hematological, biochemical and immunological parameters, as well as Magnetic resonance derived cardiac function measurements obtained from a swine myocardial infarction model. We identified some blood parameters which were significantly altered after myocardial infarction induction. More importantly, these parameters (gamma-glutamyl transferase, glutamic pyruvic transaminase, red blood cell counts, hemoglobin concentration, hematocrit, platelet count and plateletcrit) correlated positively with cardiac function, infarct size and/or cardiac enzymes (troponin I and creatine kinase-MB). Thus several blood-derived parameters have allowed us to predict the severity of myocardial infarction in a clinically relevant animal model. Therefore, here we provide a simple, affordable and reliable way that could prove useful in the follow up of myocardial infarction and in the evaluation of new therapeutic strategies in this animal model. | es_ES |
dc.description.sponsorship | This work was supported in part by CIBER-CV (CB16/11/00494), one grant from Junta de Extremadura (Ayuda a grupos catalogados de la Junta de Extremadura, GR15175), two grants from Junta de Extremadura to J.G.C. (IB16168) and V.C. (IB16201) co-financed by FEDER/FSE, two grants from ISCIII to J.G.C. (CP17/00021) and V.C. (PI16/01172) co-funded by ERDF/ESF, “Investing in your future”, and one predoctoral grant from Grupo Jorge-Mafresa to F.M. The funders had no role in study design, data collection, interpretation and analysis, decision to publish or preparation of the manuscript. | es_ES |
dc.format.extent | 9 p. | es_ES |
dc.format.mimetype | application/pdf | en_US |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.subject | Myocardial infarction | es_ES |
dc.subject | Infarto de miocardio | es_ES |
dc.subject | Porcine model | es_ES |
dc.subject | Modelo porcino | es_ES |
dc.subject | Biomarkers | es_ES |
dc.subject | Biomarcadores | es_ES |
dc.title | Altered hematological, biochemical and immunological parameters as predictive biomarkers of severity in experimental myocardial infarction | es_ES |
dc.type | article | es_ES |
dc.description.version | peerReviewed | es_ES |
europeana.type | TEXT | en_US |
dc.rights.accessRights | closedAccess | es_ES |
dc.subject.unesco | 3207.04 Patología Cardiovascular | es_ES |
dc.subject.unesco | 3109 Ciencias Veterinarias | es_ES |
europeana.dataProvider | Universidad de Extremadura. España | es_ES |
dc.identifier.bibliographicCitation | Rebeca Blázquez, Verónica Álvarez, Juan Antonio Antequera-Barroso, Claudia Báez-Díaz, Virginia Blanco, Juan Maestre, Beatriz Moreno-Lobato, Esther López, Federica Marinaro, Javier G. Casado, Verónica Crisóstomo, Francisco Miguel Sánchez-Margallo, Altered hematological, biochemical and immunological parameters as predictive biomarkers of severity in experimental myocardial infarction, Veterinary Immunology and Immunopathology, Volume 205, 2018, Pages 49-57, ISSN 0165-2427, https://doi.org/10.1016/j.vetimm.2018.10.007 | es_ES |
dc.type.version | publishedVersion | es_ES |
dc.contributor.affiliation | Centro de Cirugía de Mínima Invasión Jesús Usón. Cáceres | es_ES |
dc.contributor.affiliation | Universidad de Extremadura. Departamento de Didáctica de las Ciencias Experimentales y Matemáticas | es_ES |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S0165242718301260?via%3Dihub | es_ES |
dc.identifier.doi | 10.1016/j.vetimm.2018.10.007 | - |
dc.identifier.publicationtitle | Veterinary Immunology and Immunopathology | es_ES |
dc.identifier.publicationfirstpage | 49 | es_ES |
dc.identifier.publicationlastpage | 57 | es_ES |
dc.identifier.orcid | 0000-0001-6797-7287 | es_ES |
dc.identifier.orcid | 0000-0003-1740-7029 | es_ES |
dc.identifier.orcid | 0000-0003-2138-988X | es_ES |
Colección: | DDCEM - Artículos |
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Archivo | Descripción | Tamaño | Formato | |
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j_vetimm_2018_10_007.pdf ???org.dspace.app.webui.jsptag.ItemTag.accessRestricted??? | 2,11 MB | Adobe PDF | Descargar Pide una copia |
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