Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10662/20707
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dc.contributor.authorFernández Delgado, Elena-
dc.contributor.authorEstirado Rivera, Samuel-
dc.contributor.authorRodríguez Moratinos, Ana Beatriz-
dc.contributor.authorLuna Giles, Francisco-
dc.contributor.authorViñuelas Zahínos, Emilio-
dc.contributor.authorEspino Palma, Javier-
dc.contributor.authorPariente Llanos, José Antonio-
dc.date.accessioned2024-02-23T07:56:12Z-
dc.date.available2024-02-23T07:56:12Z-
dc.date.issued2023-
dc.identifier.issn1999-4923-
dc.identifier.urihttp://hdl.handle.net/10662/20707-
dc.description.abstractThe synthesis of analogs of cisplatin, which is a widely used chemotherapeutic agent, using other metal centers could be an alternative for cancer treatment. Pd(II) could be a substitute for Pt(II) due to its coordination chemistry similarity. For that reason, six squared-planar Pd(II) complexes with thiazine and thiazoline ligands and formula [PdCl2(L)] were synthesized and characterized in this work. The potential anticarcinogenic ability of the compounds was studied via cytotoxicity assay in three different human tumor cell lines, i.e., epithelial cervix carcinoma (HeLa), promyelocytic leukemia (HL-60), and histiocytic lymphoma (U-937). Data obtained showed that complexes with methyl substitutions did not modify cell viability, while no-methyl substituted compounds had a moderate cytotoxic effect on all three cell lines. The complexes with phenyl substitutions displayed the lowest IC50 values, which ranged between 46.39 ± 3.99 μM and 62.74 ± 6.45 μM. Moreover, Pd accumulation inside the cell was observed after incubation with any of the four complexes mentioned, and the two complexes with phenyl rings were found to induce an increase in the percentage of apoptotic cells. These results suggested that the presence of bulky substitutions on the ligands such as phenyl groups may influence the cytotoxicity of the chemotherapeutic agents synthesized.es_ES
dc.description.sponsorshipThis work was supported by Junta de Extremadura grants (ref. GR21042, GR21075, and IB18013).es_ES
dc.format.extent15 p.es_ES
dc.format.mimetypeapplication/pdfen_US
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectCytotoxicityes_ES
dc.subjectPd(II) complexeses_ES
dc.subjectApoptosises_ES
dc.subjectChemotherapeuticses_ES
dc.subjectN,S-heterocycleses_ES
dc.subjectCitotoxicidades_ES
dc.subjectApoptosises_ES
dc.subjectQuimioterapiaes_ES
dc.titleCytotoxice effects of new Palladium (II) complexes with Thiazine or Thiazoline derivative ligands in tumor cell lineses_ES
dc.typearticlees_ES
dc.description.versionpeerReviewedes_ES
europeana.typeTEXTen_US
dc.rights.accessRightsopenAccesses_ES
dc.subject.unesco2303 Química Inorgánicaes_ES
dc.subject.unesco2303.07 Compuestos de Coordinaciónes_ES
dc.subject.unesco3208.06 Quimioterapiaes_ES
europeana.dataProviderUniversidad de Extremadura. Españaes_ES
dc.identifier.bibliographicCitationFernández-Delgado, E.; Estirado, S.; Rodríguez, A.B.; Luna- Giles, F.; Viñuelas-Zahínos, E.; Espino, J.; Pariente, J.A. Cytotoxic Effects of New Palladium(II) Complexes with Thiazine or Thiazoline Derivative Ligands in Tumor Cell Lines. Pharmaceutics 2023, 15, 696. https://doi.org/10.3390/ pharmaceutics15020696es_ES
dc.type.versionacceptedVersiones_ES
dc.contributor.affiliationUniversidad de Extremadura. Departamento de Fisiologíaes_ES
dc.contributor.affiliationUniversidad de Extremadura. Departamento de Química Orgánica e Inorgánicaes_ES
dc.contributor.affiliationUniversidad de Extremadura. Grupo de Investigación Neuroinmunología y Crononutrición-
dc.relation.publisherversionhttps://www.mdpi.com/1999-4923/15/2/696es_ES
dc.identifier.doi10.3390/pharmaceutics15020696-
dc.identifier.publicationtitlePharmaceuticses_ES
dc.identifier.publicationissue2-
dc.identifier.publicationfirstpage696-1es_ES
dc.identifier.publicationlastpage696-15es_ES
dc.identifier.publicationvolume15es_ES
dc.identifier.e-issn1999-4923-
dc.identifier.orcid0000-0001-6987-6586es_ES
dc.identifier.orcid0000-0001-9958-1463es_ES
dc.identifier.orcid0000-0001-6063-0504es_ES
dc.identifier.orcid0000-0002-8188-1449es_ES
dc.identifier.orcid0000-0003-0634-1829es_ES
dc.identifier.orcid0000-0002-8549-9343es_ES
dc.identifier.orcid0000-0002-9094-9943es_ES
Colección:DQOIN - Artículos
GINyC - Artículos
GIQC - Artículos

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