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http://hdl.handle.net/10662/20707
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Campo DC | Valor | idioma |
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dc.contributor.author | Fernández Delgado, Elena | - |
dc.contributor.author | Estirado Rivera, Samuel | - |
dc.contributor.author | Rodríguez Moratinos, Ana Beatriz | - |
dc.contributor.author | Luna Giles, Francisco | - |
dc.contributor.author | Viñuelas Zahínos, Emilio | - |
dc.contributor.author | Espino Palma, Javier | - |
dc.contributor.author | Pariente Llanos, José Antonio | - |
dc.date.accessioned | 2024-02-23T07:56:12Z | - |
dc.date.available | 2024-02-23T07:56:12Z | - |
dc.date.issued | 2023 | - |
dc.identifier.issn | 1999-4923 | - |
dc.identifier.uri | http://hdl.handle.net/10662/20707 | - |
dc.description.abstract | The synthesis of analogs of cisplatin, which is a widely used chemotherapeutic agent, using other metal centers could be an alternative for cancer treatment. Pd(II) could be a substitute for Pt(II) due to its coordination chemistry similarity. For that reason, six squared-planar Pd(II) complexes with thiazine and thiazoline ligands and formula [PdCl2(L)] were synthesized and characterized in this work. The potential anticarcinogenic ability of the compounds was studied via cytotoxicity assay in three different human tumor cell lines, i.e., epithelial cervix carcinoma (HeLa), promyelocytic leukemia (HL-60), and histiocytic lymphoma (U-937). Data obtained showed that complexes with methyl substitutions did not modify cell viability, while no-methyl substituted compounds had a moderate cytotoxic effect on all three cell lines. The complexes with phenyl substitutions displayed the lowest IC50 values, which ranged between 46.39 ± 3.99 μM and 62.74 ± 6.45 μM. Moreover, Pd accumulation inside the cell was observed after incubation with any of the four complexes mentioned, and the two complexes with phenyl rings were found to induce an increase in the percentage of apoptotic cells. These results suggested that the presence of bulky substitutions on the ligands such as phenyl groups may influence the cytotoxicity of the chemotherapeutic agents synthesized. | es_ES |
dc.description.sponsorship | This work was supported by Junta de Extremadura grants (ref. GR21042, GR21075, and IB18013). | es_ES |
dc.format.extent | 15 p. | es_ES |
dc.format.mimetype | application/pdf | en_US |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | Attribution 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Cytotoxicity | es_ES |
dc.subject | Pd(II) complexes | es_ES |
dc.subject | Apoptosis | es_ES |
dc.subject | Chemotherapeutics | es_ES |
dc.subject | N,S-heterocycles | es_ES |
dc.subject | Citotoxicidad | es_ES |
dc.subject | Apoptosis | es_ES |
dc.subject | Quimioterapia | es_ES |
dc.title | Cytotoxice effects of new Palladium (II) complexes with Thiazine or Thiazoline derivative ligands in tumor cell lines | es_ES |
dc.type | article | es_ES |
dc.description.version | peerReviewed | es_ES |
europeana.type | TEXT | en_US |
dc.rights.accessRights | openAccess | es_ES |
dc.subject.unesco | 2303 Química Inorgánica | es_ES |
dc.subject.unesco | 2303.07 Compuestos de Coordinación | es_ES |
dc.subject.unesco | 3208.06 Quimioterapia | es_ES |
europeana.dataProvider | Universidad de Extremadura. España | es_ES |
dc.identifier.bibliographicCitation | Fernández-Delgado, E.; Estirado, S.; Rodríguez, A.B.; Luna- Giles, F.; Viñuelas-Zahínos, E.; Espino, J.; Pariente, J.A. Cytotoxic Effects of New Palladium(II) Complexes with Thiazine or Thiazoline Derivative Ligands in Tumor Cell Lines. Pharmaceutics 2023, 15, 696. https://doi.org/10.3390/ pharmaceutics15020696 | es_ES |
dc.type.version | acceptedVersion | es_ES |
dc.contributor.affiliation | Universidad de Extremadura. Departamento de Fisiología | es_ES |
dc.contributor.affiliation | Universidad de Extremadura. Departamento de Química Orgánica e Inorgánica | es_ES |
dc.contributor.affiliation | Universidad de Extremadura. Grupo de Investigación Neuroinmunología y Crononutrición | - |
dc.relation.publisherversion | https://www.mdpi.com/1999-4923/15/2/696 | es_ES |
dc.identifier.doi | 10.3390/pharmaceutics15020696 | - |
dc.identifier.publicationtitle | Pharmaceutics | es_ES |
dc.identifier.publicationissue | 2 | - |
dc.identifier.publicationfirstpage | 696-1 | es_ES |
dc.identifier.publicationlastpage | 696-15 | es_ES |
dc.identifier.publicationvolume | 15 | es_ES |
dc.identifier.e-issn | 1999-4923 | - |
dc.identifier.orcid | 0000-0001-6987-6586 | es_ES |
dc.identifier.orcid | 0000-0001-9958-1463 | es_ES |
dc.identifier.orcid | 0000-0001-6063-0504 | es_ES |
dc.identifier.orcid | 0000-0002-8188-1449 | es_ES |
dc.identifier.orcid | 0000-0003-0634-1829 | es_ES |
dc.identifier.orcid | 0000-0002-8549-9343 | es_ES |
dc.identifier.orcid | 0000-0002-9094-9943 | es_ES |
Colección: | DQOIN - Artículos GINyC - Artículos GIQC - Artículos |
Archivos
Archivo | Descripción | Tamaño | Formato | |
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pharmaceutics15020696.pdf | 1,22 MB | Adobe PDF | Descargar |
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