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http://hdl.handle.net/10662/21877
Títulos: | Long-term outcomes of an advanced hybrid closed-loop system: A focus on different subpopulations |
Autores/as: | Beato Víbora, Pilar Isabel Ambrojo López, Ana Fernández Bueso, Mercedes Gil Poch, Estela Arroyo Díez, Francisco Javier |
Palabras clave: | Type 1 diabetes;Diabetes tipo 1;Closed-loop systems;Sistemas de circuito cerrado;Artificial pancreas;Páncreas artificial;Hypoglycaemia;Hipoglucemia |
Fecha de publicación: | 2022 |
Editor/a: | Elsevier |
Resumen: | BACKGROUND: The long-term benefit provided by advanced hybrid closed-loop (AHCL) systems needs to be assessed in general populations and specific subpopulations. METHODS: A prospective evaluation of subjects initiating the AHCL system 780G was performed. Time in range (70–180 mg/dl) (TIR), <70 mg/dl, <54 mg/dl, >180 mg/dl and >250 mg/dl were compared, at baseline and after one year, in different subpopulations, according to previous treatment (pump vs MDI), age (> or ≤25 years old) and hypoglycaemia risk at baseline. RESULTS: 135 subjects were included (age: 35 ± 15 years, 64 % females, diabetes duration: 21 ± 12 years). An increase in TIR was found, from 67.26 ± 11.80 % at baseline to 77.41 ± 8.85 % after one year (p < 0.001). All the subgroups showed a significant improvement in TIR, time > 180 mg/dl and >250 mg/dl. At the 1-year evaluation, no significant differences were found, between previous pump users and MDI subjects. Children and young adults had a lower time < 70 mg/dl than adults. Subjects with a high risk of hypoglycaemia at baseline had a higher time spent at <70 mg/dl and <54 mg/dl than low-risk individuals. CONCLUSION: The initial benefit provided by the AHCL system is sustained in the long term. MDI subjects obtain the same outcomes as subjects with pump experience. |
Descripción: | Publicado en: Diabetes Research and Clinical Practice. 2022;191:110052. ISSN 0168-8227. https://doi.org/10.1016/j.diabres.2022.110052 |
URI: | http://hdl.handle.net/10662/21877 |
ISSN: | 0168-8227 |
DOI: | 10.1016/j.diabres.2022.110052 |
Colección: | DCBIO - Artículos |
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