Please use this identifier to cite or link to this item:
http://hdl.handle.net/10662/20102
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ayuso Parejo, Pedro | - |
dc.contributor.author | Plaza Serón, María Carmen | - |
dc.contributor.author | Blanca López, Natalia | - |
dc.contributor.author | Doña, Inmaculada | - |
dc.contributor.author | Campo, Paloma | - |
dc.contributor.author | Canto, Gabriela | - |
dc.contributor.author | Laguna, Jose Julio | - |
dc.contributor.author | Bartra, Joan | - |
dc.contributor.author | Soriano Gomis, Victor | - |
dc.contributor.author | Blanca Gómez, Miguel | - |
dc.contributor.author | Cornejo García, José Antonio | - |
dc.contributor.author | - | |
dc.date.accessioned | 2024-02-07T07:28:57Z | - |
dc.date.available | 2024-02-07T07:28:57Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1462-2416 | - |
dc.identifier.uri | http://hdl.handle.net/10662/20102 | - |
dc.description.abstract | Aim: NSAIDs are the most frequent cause of hypersensitivity drug reactions. We have examined the association between NSAIDs-exacerbated respiratory disease (NERD) and genetic variants in arachidonic acid metabolism genes. Patients & methods: We included 250 NERD patients, 260 NSAID-tolerant asthmatic (NTA) subjects and 315 healthy controls. Results: Significant associations with NERD were identified for: ALOX15 rs3892408 C/C homozygous genotype (NERD vs NTA; p = 0.0001, pc = 0.0011; NERD vs controls; p = 0.0001, pc = 0.0011), PTGS-1 rs5789 A/A homozygous genotype (NERD vs NTA; p = 0.0001, pc = 0.0011; NERD vs controls; p = 0.0001, pc = 0.0011), PTGS- 1 rs10306135 A/A homozygous genotype (NERD vs NTA; p = 0.0009, pc = 0.0091; NERD vs controls; p = 0.0064, pc = 0.045). Differences in ALOX5 copy number variations were also found (NERD vs NTA; p = 0.010; NERD vs controls; p = 0.0001). Conclusion: These results improve our understanding of the underlying mechanisms of NERD and may help develop a predictive test for this pathology | es_ES |
dc.format.extent | 15 | es_ES |
dc.format.mimetype | application/pdf | en_US |
dc.language.iso | eng | es_ES |
dc.publisher | Future Medicine | es_ES |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | ácido araquidónico, AINEs, polimorfismos | es_ES |
dc.subject | arachidonic acid, NSAIDs, polymorphisms | es_ES |
dc.title | Genetic variants in arachidonic acid pathway genes associated with NSAIDs-exacerbated respiratory disease | es_ES |
dc.type | article | es_ES |
dc.description.version | peerReviewed | es_ES |
europeana.type | TEXT | en_US |
dc.rights.accessRights | openAccess | es_ES |
dc.subject.unesco | 3209 Farmacología | es_ES |
europeana.dataProvider | Universidad de Extremadura. España | es_ES |
dc.type.version | publishedVersion | es_ES |
dc.contributor.affiliation | Universidad de Extremadura. Departamento de Terapéutica Médico-Quirúrgica | es_ES |
dc.relation.publisherversion | 10.2217/pgs.15.43 | es_ES |
dc.identifier.publicationtitle | Pharmacogenomics | es_ES |
Appears in Collections: | DTMQU - Artículos |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
pgs_15_43.pdf ???org.dspace.app.webui.jsptag.ItemTag.accessRestricted??? | Genetic variants in arachidonic acid pathway genes associated with NSAIDs-exacerbated respiratory disease | 951,77 kB | Adobe PDF | View/Open Request a copy |
This item is licensed under a Creative Commons License