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http://hdl.handle.net/10662/20196
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Campo DC | Valor | idioma |
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dc.contributor.author | Doña, Inmaculada | - |
dc.contributor.author | Jurado Escobar, Raquel | - |
dc.contributor.author | Perkins, James R. | - |
dc.contributor.author | Ayuso Parejo, Pedro | - |
dc.contributor.author | Plaza Serón, María Carmen | - |
dc.contributor.author | Pérez Sánchez, Natalia | - |
dc.contributor.author | Campo Mozo, Paloma | - |
dc.contributor.author | Bogas Herrera, Gádor | - |
dc.contributor.author | Bartra, Joan | - |
dc.contributor.author | Torres Jaén, María José | - |
dc.contributor.author | Sanak, Marek | - |
dc.contributor.author | Cornejo García, José Antonio | - |
dc.date.accessioned | 2024-02-07T10:04:48Z | - |
dc.date.available | 2024-02-07T10:04:48Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 0105-4538 | - |
dc.identifier.issn | 1398-9995 | - |
dc.identifier.uri | http://hdl.handle.net/10662/20196 | - |
dc.description.abstract | Background: The role of arachidonic acid metabolites in NSAID‐induced hypersensi- tivity has been studied in depth for NSAID‐exacerbated respiratory disease (NERD) and NSAID‐exacerbated cutaneous disease (NECD). However, no information is available for NSAID‐induced urticarial/angioedema (NIUA), despite it being the most frequent clinical entity induced by NSAID hypersensitivity. We evaluated changes in leukotriene and prostaglandin metabolites for NIUA patients, using patients with NECD and single‐NSAID‐induced urticaria/angioedema or anaphylaxis (SNIUAA) for comparison. Methods: Urine samples were taken from patients with confirmed NSAID‐induced urticaria and healthy controls, at baseline and at various time intervals after ASA administration. Eicosanoid measurement was performed using high‐performance liquid chromatography‐tandem mass spectrometry and gas chromatography‐mass spectrometry. Results: No differences were found between groups at baseline. Following ASA administration, LTE4 and 9α,11β‐PGF2 levels were increased in both NIUA and NECD patients compared to baseline, rising initially, before decreasing toward initial levels. In addition, the levels of these metabolites were higher in NIUA and NECD when compared with the SNIUAA and control groups after ASA administration. No changes were found with respect to baseline values for SNIUAA and control groups. Conclusions: We present for the first time data regarding the role of COX‐1 inhibi- tion in NIUA. Patients with this entity show a similar pattern eicosanoid levels fol- lowing ASA challenge to those with NECD. Further studies will help ascertain the cell populations involved and the underlying molecular mechanisms. | es_ES |
dc.description.sponsorship | This work was supported by grants co-funded by the European Regional Development Fund (ERDF), from the Carlos III National Health Institute (ARADyAL Network RD16/0006/0001 and RD16/0006/0007, and PI17/01593). I Doña is a researcher from the Juan Rodés Program (Ref JR15/0036), JR Perkins from the Sara Borrell Program (Ref CD14/00242), and JA Cornejo-García from the Miguel Servet Program (Ref CP14/00034), all from the Carlos III National Health Institute, Spanish Ministry of Economy and Competitiveness. We thank Dr. Tatiana Díaz and the Malaga Hospital-IBIMA Biobank, belonging to the Andalusian Public Health System Biobank and the National Biobank Platform (Project PT13/0010/0006, PT13/0010/0033), for sample management. | - |
dc.format.extent | 10 p. | es_ES |
dc.format.mimetype | application/pdf | en_US |
dc.language.iso | eng | es_ES |
dc.publisher | John Wiley and Sons Ltd. | es_ES |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Hipersensibilidad a fármacos | es_ES |
dc.subject | Drug hypersensitivity | es_ES |
dc.subject | Eicosanoids | - |
dc.subject | Antiinflamatorios no esteroideos | - |
dc.subject | Non-steroidal antiinflammatory | - |
dc.subject | Eicosanoides | - |
dc.title | Eicosanoid mediator profiles in different phenotypes of nonsteroidal anti‐inflammatory drug‐induced urticaria | es_ES |
dc.type | article | es_ES |
dc.description.version | peerReviewed | es_ES |
europeana.type | TEXT | en_US |
dc.rights.accessRights | closedAccess | es_ES |
dc.subject.unesco | 3209.03 Evaluación de Medicamentos | es_ES |
europeana.dataProvider | Universidad de Extremadura. España | es_ES |
dc.identifier.bibliographicCitation | Doña I, Jurado-Escobar R, Perkins JR, et al. Eicosanoid mediator profiles in different phenotypes of nonsteroidal anti-inflammatory drug-induced urticaria. Allergy. 2019; 74: 1135–1144. https://doi.org/10.1111/all.13725 | - |
dc.type.version | publishedVersion | es_ES |
dc.contributor.affiliation | Universidad de Extremadura. Departamento de Terapéutica Médico-Quirúrgica | es_ES |
dc.contributor.affiliation | Universitat de Barcelona | - |
dc.contributor.affiliation | Jagiellonian University Medical College. Polonia | - |
dc.relation.publisherversion | https://onlinelibrary.wiley.com/doi/10.1111/all.13725 | es_ES |
dc.identifier.doi | 10.1111/all.13725 | - |
dc.identifier.publicationtitle | Allergy | es_ES |
dc.identifier.publicationissue | 6 | es_ES |
dc.identifier.publicationfirstpage | 1135 | es_ES |
dc.identifier.publicationlastpage | 1144 | es_ES |
dc.identifier.publicationvolume | 74 | - |
dc.identifier.orcid | 0000-0002-9441-4022 | es_ES |
Colección: | DTMQU - Artículos |
Archivos
Archivo | Descripción | Tamaño | Formato | |
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all_13725.pdf ???org.dspace.app.webui.jsptag.ItemTag.accessRestricted??? | 867,4 kB | Adobe PDF | Descargar Pide una copia |
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