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http://hdl.handle.net/10662/20211
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Campo DC | Valor | idioma |
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dc.contributor.author | Perkins, James R. | - |
dc.contributor.author | Ayuso Parejo, Pedro | - |
dc.contributor.author | Cornejo García, José Antonio | - |
dc.contributor.author | Ranea, Juan A | - |
dc.date.accessioned | 2024-02-07T10:30:20Z | - |
dc.date.available | 2024-02-07T10:30:20Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | 10.1097/ACI.0000000000000076 | - |
dc.identifier.issn | 1528-4050 | - |
dc.identifier.issn | 1473-6322 | - |
dc.identifier.uri | http://hdl.handle.net/10662/20211 | - |
dc.description.abstract | Purpose of review Stevens–Johnson syndrome and toxic epidermal necrolysis are severe hypersensitivity reactions, the majority of which are drug induced. The underlying mechanisms are not fully understood. Here, we review recent findings concerning both mechanistic and genetic factors related to these diseases and propose future approaches to unravel their complexity. Recent findings Genome-wide association study studies have identified several variants in the human leukocyte antigen region associated with these reactions. These are highly dependent on the population studied and the triggering drug. The T-cell receptor repertoire of the patient is also key. Fas–Fas ligand interactions, perforin and granulysin have also been identified as important players. Furthermore, a high-throughput gene expression study has identified a number of genes that increase in expression in patients during the acute phase of these reactions. Summary We review recent high-throughput studies on these diseases and suggest ways in which the data can be combined and reanalyzed using integrative systems biology techniques. We also suggest future lines of research using recent technology that could shed further light on their underlying mechanisms. | es_ES |
dc.description.sponsorship | This work has been supported by grants from Carlos III National Health Institute RD12/0013/0001 (RIRAAF network), FIS PI12/02247 and CIBER de Enfermedades Raras; Marie Curie (IAPP 7th Framework Program Mr. SymBioMath, no. 324554); European Commission: Systems Microscopy consortium (FP7/2007-2013-258068); Spanish Ministry of Economy and Competitiveness (SAF2012-33110); Andalusian Government and FEDER (CTS-486); and The Health Government of Andalusia (PI-0279-2013). | - |
dc.format.extent | 6 p. | es_ES |
dc.format.mimetype | application/pdf | en_US |
dc.language.iso | eng | es_ES |
dc.publisher | Lippincott Williams & Wilkins | es_ES |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Biología de sistemas | es_ES |
dc.subject | Systems Biology | es_ES |
dc.subject | Síndrome Steven-Johnson | - |
dc.subject | Células T | - |
dc.subject | Steven-Johnson syndrome | - |
dc.subject | T cells | - |
dc.subject | Human leukocyte antigen | - |
dc.subject | Antígeno leucocitario humano | - |
dc.subject | Hypersensitivity drug reactions | - |
dc.subject | Reacciones de hipersensibilidad a los medicamentos | - |
dc.subject | Toxic epidermal necrolysis | - |
dc.subject | Necrólisis epidérmica tóxica | - |
dc.title | The study of severe cutaneous drug hypersensitivity reactions from a systems biology perspective | es_ES |
dc.type | article | es_ES |
dc.description.version | peerReviewed | es_ES |
europeana.type | TEXT | en_US |
dc.rights.accessRights | closedAccess | es_ES |
dc.subject.unesco | 3209 Farmacología | es_ES |
dc.subject.unesco | 3207.01 Alergias | es_ES |
europeana.dataProvider | Universidad de Extremadura. España | es_ES |
dc.identifier.bibliographicCitation | Perkins, James R.; Ayuso, Pedro; Cornejo-García, José A.; Ranea, Juan A.. The study of severe cutaneous drug hypersensitivity reactions from a systems biology perspective. Current Opinion in Allergy and Clinical Immunology 14(4):p 301-306, August 2014. | DOI: 10.1097/ACI.0000000000000076 | - |
dc.type.version | publishedVersion | es_ES |
dc.contributor.affiliation | Universidad de Extremadura. Departamento de Terapéutica Médico-Quirúrgica | es_ES |
dc.contributor.affiliation | Universidad de Málaga | - |
dc.relation.publisherversion | https://journals.lww.com/co-allergy/abstract/2014/08000/the_study_of_severe_cutaneous_drug.7.aspx | es_ES |
dc.identifier.publicationtitle | Current Opinion | es_ES |
dc.identifier.publicationissue | 4 | es_ES |
dc.identifier.publicationfirstpage | 301 | es_ES |
dc.identifier.publicationlastpage | 306 | es_ES |
dc.identifier.publicationvolume | 14 | - |
dc.identifier.orcid | 0000-0002-9441-4022 | es_ES |
Colección: | DTMQU - Artículos |
Archivos
Archivo | Descripción | Tamaño | Formato | |
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ACI_0000000000000076.pdf ???org.dspace.app.webui.jsptag.ItemTag.accessRestricted??? | 139,72 kB | Adobe PDF | Descargar Pide una copia |
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