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http://hdl.handle.net/10662/20989
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Campo DC | Valor | idioma |
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dc.contributor.author | Gervasini Rodríguez, Guillermo | - |
dc.contributor.author | Verde Rello, Zoraida | - |
dc.contributor.author | González García, Luz María | - |
dc.contributor.author | Chicharro Miguel, Celia | - |
dc.contributor.author | González Rodríguez, Laura | - |
dc.contributor.author | Fernández Araque, Ana María | - |
dc.contributor.author | Mota Zamorano, Sonia | - |
dc.contributor.author | Cancho Castellano, Bárbara | - |
dc.contributor.author | Pérez Hernández, Alberto | - |
dc.contributor.author | García López, Virginio | - |
dc.contributor.author | Bandrés Moya, Fernando | - |
dc.contributor.author | Robles Pérez-Monteoliva, Nicolás Roberto | - |
dc.date.accessioned | 2024-04-02T12:10:40Z | - |
dc.date.available | 2024-04-02T12:10:40Z | - |
dc.date.issued | 2023 | - |
dc.identifier.uri | http://hdl.handle.net/10662/20989 | - |
dc.description.abstract | There is a pressing need for more precise biomarkers of chronic kidney disease (CKD). Plasma samples from 820 subjects [231 with CKD, 325 with end-stage kidney disease (ESKD) and 264 controls] were analyzed by liquid chromatography with tandem mass spectrometry (LC-MS/MS) to determine a metabolic profile of 28 amino acids (AAs) and biogenic amines to test their value as markers of CKD risk and progression. The kynurenine/tryptophan ratio showed the strongest correlation with estimated glomerular filtration rate values (coefficient = -0.731, p < 0.0001). Models created with orthogonal partial least squares-discriminant analysis (OPLS-DA) containing the metabolic signature showed a high goodness of fit and predictability for controls/CKD (R2X:0.73:R2Y:0.92:Q2:0.92, p < 0.0001) and lower values for CKD/ESKD (R2X:0.56:R2Y:0.59:Q2:0.55, p < 0.0001). Based on generated VIP scores, the most relevant markers for segregating samples into control/CKD and CKD/ESKD groups were citrulline (1.63) and tryptophan (1.47), respectively. ROC analysis showed that the addition of the metabolic profile to a model including CKD classic risk factors improved the AUC from 86.7% (83.6-89.9) to 100% (100-100) for CKD risk (p < 0.0001) and from 63.0% (58.2-67.8) to 96.5% (95.3-97.8) for the risk of progression from CKD to ESKD (p < 0.0001). Plasma concentrations of AAs and related amines may be useful as diagnostic biomarkers of kidney disease, both for CKD risk and for progression of CKD patients to ESKD. | es_ES |
dc.description.sponsorship | This research was funded by grant RD21/0005/0031 from Instituto de Salud Carlos III, Madrid (Spain), financed by the European Union-NextGeneration UE, Recovery and Resilience Mechanism, grant PI22/00181 funded by Instituto de Salud Carlos III (ISCIII) and co-funded by the European Union and grant GR21026 from Junta de Extremadura, Mérida (Spain) and Fondo Europeo de Desarrollo Regional (FEDER) “Una manera de hacer Europa” | es_ES |
dc.format.extent | 13 p. | es_ES |
dc.format.mimetype | application/pdf | en_US |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | Attribution 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Aminoácidos | es_ES |
dc.subject | Enfermedad renal crónica | es_ES |
dc.subject | Enfermedad renal terminal | es_ES |
dc.subject | Metabolitos | es_ES |
dc.subject | Amino acids | es_ES |
dc.subject | Chronic kidney disease | es_ES |
dc.subject | End-stage kidney disease | es_ES |
dc.subject | Metabolites | es_ES |
dc.title | Prognostic significance of amino acid and biogenic amines profiling in chronic kidney disease | es_ES |
dc.type | article | es_ES |
dc.description.version | peerReviewed | es_ES |
europeana.type | TEXT | en_US |
dc.rights.accessRights | openAccess | es_ES |
dc.subject.unesco | 3205.06 Nefrología | es_ES |
dc.subject.unesco | 2302.02 Aminoácidos | es_ES |
dc.subject.unesco | 2302 Bioquímica | es_ES |
europeana.dataProvider | Universidad de Extremadura. España | es_ES |
dc.identifier.bibliographicCitation | Gervasini, G.; Verde, Z.; González, L.M.; Chicharro, C.; González-Rodríguez, L.; Fernández-Araque, A.; Mota-Zamorano, S.; Cancho, B.; Pérez-Hernández, A.; García-López, V.; et al. Prognostic Significance of Amino Acid and Biogenic Amines Profiling in Chronic Kidney Disease. Biomedicines 2023, 11, 2775. https://doi.org/10.3390/ biomedicines11102775 | es_ES |
dc.type.version | publishedVersion | es_ES |
dc.contributor.affiliation | Universidad de Extremadura. Instituto Universitario de Biomarcadores de Patologías Metabólicas y Moleculares | es_ES |
dc.contributor.affiliation | Universidad de Extremadura. Departamento de Terapéutica Médico-Quirúrgica | es_ES |
dc.contributor.affiliation | Universidad de Valladolid | - |
dc.contributor.affiliation | Universidad Complutense de Madrid | - |
dc.relation.publisherversion | https://www.mdpi.com/2227-9059/11/10/2775 | es_ES |
dc.identifier.doi | 10.3390/biomedicines11102775 | - |
dc.identifier.publicationtitle | Biomedicines | es_ES |
dc.identifier.publicationissue | 10 | es_ES |
dc.identifier.publicationfirstpage | 2775-1 | es_ES |
dc.identifier.publicationlastpage | 2775-13 | es_ES |
dc.identifier.publicationvolume | 11 | es_ES |
dc.identifier.e-issn | 227-9059 | - |
dc.identifier.orcid | 0000-0003-1489-7296 | es_ES |
dc.identifier.orcid | 0000-0003-4984-6691 | es_ES |
dc.identifier.orcid | 0000-0002-0524-9767 | es_ES |
Colección: | DTMQU - Artículos IBPM - Artículos |
Archivos
Archivo | Descripción | Tamaño | Formato | |
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biomedicines11102775.pdf | 2,57 MB | Adobe PDF | Descargar |
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