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http://hdl.handle.net/10662/21358
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Campo DC | Valor | idioma |
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dc.contributor.author | Ruiz Tapia, Patricia | - |
dc.contributor.author | Durán Galea, Ángela | - |
dc.contributor.author | Duque Carrasco, Francisco Javier | - |
dc.contributor.author | González, Mario Alberto | - |
dc.contributor.author | Cristóbal Verdejo, José Ignacio | - |
dc.contributor.author | Nicolás Barceló, Paloma | - |
dc.contributor.author | Pérez Merino, Eva María | - |
dc.contributor.author | Macías García, Beatriz | - |
dc.contributor.author | Barrera Chacón, Rafael | - |
dc.date.accessioned | 2024-06-03T08:10:59Z | - |
dc.date.available | 2024-06-03T08:10:59Z | - |
dc.date.issued | 2023 | - |
dc.identifier.issn | 0304-4017 | - |
dc.identifier.uri | http://hdl.handle.net/10662/21358 | - |
dc.description.abstract | Canine leishmaniasis (CanL) is a disease caused by Leishmania infantum that can vary from a subclinical infection to a severe disease. Dogs affected with CanL present varying degrees of renal dysfunction. Unfortunately, traditional biomarkers such as urea and creatinine detect renal damage in advanced stages of the disease, so more accurate biomarkers are needed. Hence, we aimed to study how urinary cystatin C (CysC) and N-acetyl-beta-Dglucosaminidase (NAG), behave in dogs with CanL at different stages of the disease. Eighty-six CanL infected dogs were classified according to LeishVet stages: LI (16 dogs), LIIa (12 dogs), LIIb (12 dogs), LIII (16 dogs) and LIV (30 dogs); as a control, 17 healthy dogs were studied. Blood samples were collected for complete haematological and biochemistry analysis including plasma cystatin C. Urine analysis included urine specific gravity (USG), urine protein to creatinine ratio (UPC), CysC and NAG expressed as a ratio with creatinine uCysCc (μg/g) and uNAGc (IU/g). The haematological, biochemical and urinary analysis coincided with the LeishVet guidelines. The statistical study of the uCysCc ratio and the uNAGc, showed significant increase when compared against control starting from group LI (p < 0.05). Interestingly, when the cut-off values were calculated using the ROC curve, uCysCc (258.85 μg/g) and uNAGc (2.25 IU/g) 75 % of the dogs included in LI groups surpassed the threshold. Hence our study indicates that uCysCc and uNAGc, could help to detect early renal damage in CanL affected dogs. | es_ES |
dc.description.sponsorship | Beatriz Macías-García is funded by the RYC-2017-21545 grant funded by MCIN/AEI/ and, by “ESF Investing in your future” | es_ES |
dc.format.extent | 9 p. | es_ES |
dc.format.mimetype | application/pdf | en_US |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Leishmaniosis canina | es_ES |
dc.subject | Biomarcadores | es_ES |
dc.subject | Cistatina C | es_ES |
dc.subject | N-acetil-beta-D-glucosaminidasa (NGA) | es_ES |
dc.subject | Canine leishmaniasis | es_ES |
dc.subject | Biomarkers | es_ES |
dc.subject | Cystatin C | es_ES |
dc.subject | N-acetyl-beta-Dglucosaminidase (NAG), | es_ES |
dc.title | Urinary cystatin C and N-acetyl-beta-D-glucosaminidase (NAG) as early biomarkers for renal disease in dogs with leishmaniosis | es_ES |
dc.type | article | es_ES |
dc.description.version | peerReviewed | es_ES |
europeana.type | TEXT | en_US |
dc.rights.accessRights | openAccess | es_ES |
dc.subject.unesco | 3109 Ciencias Veterinarias | es_ES |
dc.subject.unesco | 2401.12 Parasitología Animal | es_ES |
europeana.dataProvider | Universidad de Extremadura. España | es_ES |
dc.identifier.bibliographicCitation | Ruiz Tapia, P., Durán Galea, A., Duque Carrasco, F.J., González, M.A., Cristóbal Verdejo, J.I., Nicolás Barceló, P., Pérez Merino, E.M., Macías García, B., Barrera Chacón, R. (2023). Urinary cystatin C and N-acetyl-beta-D-glucosaminidase (NAG) as early biomarkers for renal disease in dogs with leishmaniosis. Veterinary Parasitology, 318, 1-9. https://doi.org/10.1016/j.vetpar.2023.109930016 | es_ES |
dc.type.version | publishedVersion | es_ES |
dc.contributor.affiliation | Universidad de Extremadura. Hospital Clínico Veterinario | es_ES |
dc.contributor.affiliation | Universidad de Extremadura. Departamento de Medicina Animal | es_ES |
dc.relation.publisherversion | https://pubmed.ncbi.nlm.nih.gov/37030024/ | es_ES |
dc.identifier.doi | 10.1016/j.vetpar.2023.109930 | - |
dc.identifier.publicationtitle | Veterinary Parasitology | es_ES |
dc.identifier.publicationfirstpage | 109930-1 | es_ES |
dc.identifier.publicationlastpage | 109930-9 | es_ES |
dc.identifier.publicationvolume | 318 | - |
dc.identifier.e-issn | 1873-2550 | - |
dc.identifier.orcid | 0000-0003-2415-6707 | es_ES |
dc.identifier.orcid | 0000-0003-2952-0184 | es_ES |
dc.identifier.orcid | 0000-0003-3110-6062 | es_ES |
dc.identifier.orcid | 0000-0001-9015-7690 | es_ES |
dc.identifier.orcid | 0000-0002-9118-1139 | es_ES |
dc.identifier.orcid | 0000-0001-5331-9793 | es_ES |
dc.identifier.orcid | 0000-0003-3341-7331 | es_ES |
Colección: | DMANI - Artículos |
Archivos
Archivo | Descripción | Tamaño | Formato | |
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j_vetpar_2023_09930.pdf | 1,04 MB | Adobe PDF | Descargar |
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