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http://hdl.handle.net/10662/7272
| Title: | An easy synthesis of diversely functionalized 2H-chromenes and amido amines by an enol-Ugi reaction |
| Authors: | Gómez Neo, Ana María González Castellano, María Teresa Fernández Marcos, Carlos María |
| Keywords: | Reacciones multicomponente;Enoles;Benzopirenos;Cumarina;Productos naturales;Química combinatoria |
| Issue Date: | 2016 |
| Publisher: | Michigan Publishing |
| Abstract: | The first synthesis of methyl 2-(4-hydroxy-2-oxo-2H-chromen-3-yl)-2-oxoacetate is described. This compound has been successfully used in a multicomponent enol-Ugi condensation with imines and isocyanides affording 4-aminoacyl-coumarin enamines in a highly atom-economic and convergent process. Furthermore, the postcondensation transformation of these adducts allows the straightforward synthesis of both unprotected amino amides and as yet unknown 2-hydroxychromenyl enamines. |
| URI: | http://hdl.handle.net/10662/7272 |
| ISSN: | 1551-7102 |
| DOI: | 10.3998/ark.5550190.p009.775 |
| Appears in Collections: | DQOIN - Artículos |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| ark_5550190_p009_775.pdf | 737,13 kB | Adobe PDF | View/Open |
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