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http://hdl.handle.net/10662/8264
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Campo DC | Valor | idioma |
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dc.contributor.author | Rodríguez Trabado, Ana | - |
dc.contributor.author | Cámara Hijón, Carmen | - |
dc.contributor.author | Ramos Cantariño, Alfonso | - |
dc.contributor.author | Romero Chala, Silvia | - |
dc.contributor.author | García Trujillo, José Antonio | - |
dc.contributor.author | Fernández Pereira, Luis Miguel | - |
dc.date.accessioned | 2018-11-23T11:31:37Z | - |
dc.date.available | 2018-11-23T11:31:37Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 2092-7355 | - |
dc.identifier.uri | http://hdl.handle.net/10662/8264 | - |
dc.description.abstract | PURPOSE: The basophil activation test (BAT) has been used to monitor venom immunotherapy (VIT) due to its high specificity. A previous study has reported a good correlation between a significant decrease in basophil activation during 5 years of VIT and clinical protection assessed by sting challenge. The following prospective study was performed to examine changes in basophil reactivity over a complete VIT period of 5 years. METHODS: BAT in a dose-response curve was studied prospectively in 10 hymenoptera venom-allergic patients over 5 years of VIT. BAT was performed at the time of diagnosis, 1 month after finishing the VIT build-up phase, and 3, 6, 12, 24, and 60 months after beginning treatment. The repeated measures ANOVA was applied to evaluate basophil activation changes throughout VIT. A cross-sectional study was also performed in 6 patients who received treatment for more than 3 years, and in another 12 patients who followed immunotherapy for at least 5 years. RESULTS: An early activation decrease was observed during the first 3 months of treatment, compared to pre-treatment values. This activation decrease was not maintained 6 to 18 months after treatment, but was observed again after 2 years of treatment, and maintained until the completion of the 5-year immunotherapy period. In cross-sectional analysis, the 6 patients who received treatment for 3 years, and 9 of the 12 patients who received treatment for 5 years, had negative BAT results. Three patients in this last group had positive BAT results and 2 patients had systemic reactions after field stings. CONCLUSIONS: BAT appears to be an optimal non-invasive test for close monitoring of VIT. | es_ES |
dc.description.sponsorship | • Fundesalud (Extremadura). Ayuda de promoción • Stallergenes Iberica laboratories. Ayuda en la redacción | es_ES |
dc.format.extent | 9 p. | es_ES |
dc.format.mimetype | application/pdf | en |
dc.language.iso | eng | es_ES |
dc.publisher | The Korean Academy of Asthma, Allergy and Clinical Immunology | es_ES |
dc.rights | Atribución-NoComercial-SinDerivadas 3.0 España | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.subject | Activación | es_ES |
dc.subject | Basófilo | es_ES |
dc.subject | Veneno | es_ES |
dc.subject | Inmunoterapia | es_ES |
dc.subject | CD63 | es_ES |
dc.subject | Activation | es_ES |
dc.subject | Basophil | es_ES |
dc.subject | Venom | es_ES |
dc.subject | Immunotherapy | es_ES |
dc.title | Short-, intermediate-, and long-term changes in basophil reactivity induced by venom immunotherapy | es_ES |
dc.type | article | es_ES |
dc.description.version | peerReviewed | es_ES |
europeana.type | TEXT | en_US |
dc.rights.accessRights | openAccess | es_ES |
dc.subject.unesco | 2412.07 Inmunoquímica | es_ES |
dc.subject.unesco | 3207.10 Inmunopatología | es_ES |
europeana.dataProvider | Universidad de Extremadura. España | es_ES |
dc.identifier.bibliographicCitation | Rodríguez Trabado, A.; Cámara Hijón, C.; Ramos Cantariño, A.; Romero Chala, S.; García Trujillo, J. A. y Fernández Pereira, L. M. (2016). Short-, intermediate-, and long-term changes in basophil reactivity induced by venom immunotherapy. AAIR: allergy, asthma and immunology research, 8, 5, 412-420. ESSN 2092-7363 | es_ES |
dc.type.version | publishedVersion | es_ES |
dc.contributor.affiliation | Hospital «Ciudad de Coria» | es_ES |
dc.contributor.affiliation | Hospital San Pedro de Alcántara. Cáceres | es_ES |
dc.contributor.affiliation | Universidad de Extremadura. Departamento de Matemáticas | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.4168/aair.2016.8.5.412 | es_ES |
dc.relation.publisherversion | https://e-aair.org/search.php?where=aview&id=10.4168/aair.2016.8.5.412&code=9999AAIR&vmode=FULL | es_ES |
dc.identifier.doi | 10.4168/aair.2016.8.5.412 | - |
dc.identifier.publicationtitle | AAIR: allergy, asthma and immunology research | es_ES |
dc.identifier.publicationissue | 5 | es_ES |
dc.identifier.publicationfirstpage | 412 | es_ES |
dc.identifier.publicationlastpage | 420 | es_ES |
dc.identifier.publicationvolume | 8 | es_ES |
Colección: | DMATE - Artículos |
Archivos
Archivo | Descripción | Tamaño | Formato | |
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aair_2016_8_5_412.pdf | 321,87 kB | Adobe PDF | Descargar |
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