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Title: Positioning of centrioles is a conserved readout of Frizzled planar cell polarity signalling
Authors: Carvajal González, José María
Román García, Ángel Carlos
Mlodzik, Marek
Keywords: Polaridad cellular plana;Orientación celular;Drosophila;Planar cell polarity;Cellular orientation
Issue Date: 2016
Publisher: Natural Publishing Group
Abstract: Planar cell polarity (PCP) signalling is a well-conserved developmental pathway regulating cellular orientation during development. An evolutionarily conserved pathway readout is not established and, moreover, it is thought that PCP mediated cellular responses are tissue-specific. A key PCP function in vertebrates is to regulate coordinated centriole/cilia positioning, a function that has not been associated with PCP in Drosophila. Here we report instructive input of Frizzled-PCP (Fz/PCP) signalling into polarized centriole positioning in Drosophila wings. We show that centrioles are polarized in pupal wing cells as a readout of PCP signalling, with both gain and loss-of-function Fz/PCP signalling affecting centriole polarization. Importantly, loss or gain of centrioles does not affect Fz/PCP establishment, implicating centriolar positioning as a conserved PCP-readout, likely downstream of PCP-regulated actin polymerization. Together with vertebrate data, these results suggest a unifying model of centriole/cilia positioning as a common downstream effect of PCP signalling from flies to mammals.
ISSN: 2041-1723
DOI: 10.1038/ncomms11135
Appears in Collections:DBYBM - Artículos

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