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Title: An easy synthesis of diversely functionalized 2H-chromenes and amido amines by an enol-Ugi reaction
Authors: Gómez Neo, Ana María
González Castellano, María Teresa
Fernández Marcos, Carlos María
Keywords: Reacciones multicomponente;Enoles;Benzopirenos;Cumarina;Productos naturales;Química combinatoria
Issue Date: 2016
Publisher: Michigan Publishing
Abstract: The first synthesis of methyl 2-(4-hydroxy-2-oxo-2H-chromen-3-yl)-2-oxoacetate is described. This compound has been successfully used in a multicomponent enol-Ugi condensation with imines and isocyanides affording 4-aminoacyl-coumarin enamines in a highly atom-economic and convergent process. Furthermore, the postcondensation transformation of these adducts allows the straightforward synthesis of both unprotected amino amides and as yet unknown 2-hydroxychromenyl enamines.
ISSN: 1551-7102
DOI: 10.3998/ark.5550190.p009.775
Appears in Collections:DQOIN - Artículos

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