Please use this identifier to cite or link to this item: http://hdl.handle.net/10662/7403
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dc.contributor.authorAmo Marín, Gemma-
dc.contributor.authorGarcía Menaya, Jesús Miguel-
dc.contributor.authorCampo Mozo, Paloma-
dc.contributor.authorCordobés Durán, Concepción-
dc.contributor.authorPlaza Serón, María Carmen-
dc.contributor.authorAyuso Parejo, Pedro-
dc.contributor.authorEsguevillas Cansino, Gara-
dc.contributor.authorBlanca Gómez, Miguel-
dc.contributor.authorGarcía-Agúndez Pérez-Coca, José Augusto-
dc.contributor.authorGarcía Martín, Elena-
dc.date.accessioned2018-05-09T12:19:43Z-
dc.date.available2018-05-09T12:19:43Z-
dc.date.issued2016-
dc.identifier.issn2045-2322-
dc.identifier.urihttp://hdl.handle.net/10662/7403-
dc.description.abstractAllergic rhinitis is associated with elevated serum IgE levels. IgE response is mediated by the highaffinity IgE receptor (FcεRI), which is polymorphic. Studies analyzing the association between allergic rhinitis and FcεRI variants have been conducted with controversial results. The objective of this study is to analyze, in 1,041 individuals, the putative clinical association of allergic rhinitis with common polymorphisms in FcεRI subunits genes. These SNPs included FECR1A rs2494262, rs2427837 and rs2251746; FECR1B rs1441586, rs569108 and rs512555; FCER1G rs11587213, rs2070901 and rs11421. Statistically significant differences were observed for the FCER1B rs569108 and rs512555 polymorphisms frequencies when comparing patients with allergic rhinitis without asthma and controls. The OR (95% CI) value for the 237Gly allele (rs569108) is equal to 0.26 (0.08–0.86, P = 0.017) and for the G allele (rs512555) it is equal to 0.27 (0.08–0.88, P = 0.020). These two SNPs are linked (D’ = 1.0, LOD = 56.05). Also observed was a statistically significant trend towards lower IgE values among allergic rhinitis patients with variant alleles for both SNPs. In conclusion, in patients with allergic rhinitis without asthma, the FCER1B rs569108 and rs512555 polymorphisms are associated with increased risk of developing allergic rhinitis and with lower IgE levels.es_ES
dc.description.sponsorshipTrabajo financiado por: Instituto de Salud Carlos III. Fondo de Investigación Sanitaria. Becas PI12/00241, PI12/00324 y RETICS RD12/0013/0002 Junta de Extremadura y Fondos FEDER. Ayuda GR15026es_ES
dc.format.extent7 p.es_ES
dc.language.isoenges_ES
dc.publisherNature Publishing Groupes_ES
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subjectRinitis alérgicaes_ES
dc.subjectNiveles de IgE en sueroes_ES
dc.subjectAsmaes_ES
dc.subjectAllergic rhinitises_ES
dc.subjectSerum IgE levelses_ES
dc.subjectAsthmaes_ES
dc.titleA nonsynonymous FCER1B SNP is associated with risk of developing allergic rhinitis and with IgE levelses_ES
dc.typearticlees_ES
dc.description.versionpeerReviewedes_ES
dc.rights.accessRightsopenAccesses_ES
dc.subject.unesco3207.01 Alergiases_ES
dc.subject.unesco3205.08 Enfermedades Pulmonareses_ES
dc.identifier.bibliographicCitationAmo Marín, G.; García Menaya, J. M.; Campo Mozo, P. ; Cordobés Durán, C.; Plaza Serón, M. C.; Ayuso Parejo, P.; Esguevillas Cansino, G. [et al.]. (2016). A nonsynonymous FCER1B SNP is associated with risk of developing allergic rhinitis and with IgE levels. Scientific reports, 6, 19724. ESSN 2045-2322es_ES
dc.type.versionpublishedVersiones_ES
dc.contributor.affiliationHospital Universitario Infanta Cristina. Badajozes_ES
dc.contributor.affiliationUniversidad de Extremadura. Departamento de Terapéutica Médico-Quirúrgicaes_ES
dc.contributor.affiliationHospital Regional Universitario Carlos Haya. Málaga-
dc.contributor.affiliationHospital Universitario Virgen de la Victoria. Málaga-
dc.relation.publisherversionhttps://www.nature.com/articles/srep19724es_ES
dc.identifier.doi10.1038/srep19724-
dc.identifier.publicationtitleScientific reportses_ES
dc.identifier.publicationfirstpage1es_ES
dc.identifier.publicationlastpage7es_ES
dc.identifier.publicationvolume6, 19724es_ES
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