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Title: A nonsynonymous FCER1B SNP is associated with risk of developing allergic rhinitis and with IgE levels
Authors: Amo Marín, Gemma
García Menaya, Jesús Miguel
Campo Mozo, Paloma
Cordobés Durán, Concepción
Plaza Serón, María Carmen
Ayuso Parejo, Pedro
Esguevillas Cansino, Gara
Blanca Gómez, Miguel
García-Agúndez Pérez-Coca, José Augusto
García Martín, Elena
Keywords: Rinitis alérgica;Niveles de IgE en suero;Asma;Allergic rhinitis;Serum IgE levels;Asthma
Issue Date: 2016
Publisher: Nature Publishing Group
Abstract: Allergic rhinitis is associated with elevated serum IgE levels. IgE response is mediated by the highaffinity IgE receptor (FcεRI), which is polymorphic. Studies analyzing the association between allergic rhinitis and FcεRI variants have been conducted with controversial results. The objective of this study is to analyze, in 1,041 individuals, the putative clinical association of allergic rhinitis with common polymorphisms in FcεRI subunits genes. These SNPs included FECR1A rs2494262, rs2427837 and rs2251746; FECR1B rs1441586, rs569108 and rs512555; FCER1G rs11587213, rs2070901 and rs11421. Statistically significant differences were observed for the FCER1B rs569108 and rs512555 polymorphisms frequencies when comparing patients with allergic rhinitis without asthma and controls. The OR (95% CI) value for the 237Gly allele (rs569108) is equal to 0.26 (0.08–0.86, P = 0.017) and for the G allele (rs512555) it is equal to 0.27 (0.08–0.88, P = 0.020). These two SNPs are linked (D’ = 1.0, LOD = 56.05). Also observed was a statistically significant trend towards lower IgE values among allergic rhinitis patients with variant alleles for both SNPs. In conclusion, in patients with allergic rhinitis without asthma, the FCER1B rs569108 and rs512555 polymorphisms are associated with increased risk of developing allergic rhinitis and with lower IgE levels.
ISSN: 2045-2322
DOI: 10.1038/srep19724
Appears in Collections:DTMQU - Artículos

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