Dietary intake of cadmium, lead and mercury and its association with bone health in healthy premenopausal women

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Dietary intake of cadmium, lead and mercury and its association with bone health in healthy premenopausal women

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Title: Dietary intake of cadmium, lead and mercury and its association with bone health in healthy premenopausal women
Author: Lavado García, Jesús María; Puerto Parejo, Luis Manuel; Roncero Martín, Raul; Morán García, Jose María; Pedrera Zamorano, Juan Diego; Aliaga Vera, Ignacio Joaquín; Leal Hernández, Olga; Canal Macías, María Luz
Abstract: El hueso es uno de los órganos diana relevantes de los metales pesados, y la toxicidad de los metales pesados está asociada con varios procesos degenerativos, como la osteoporosis y las alteraciones de los minerales óseos, que podrían provocar fracturas. El objetivo fue estudiar una presunta relación entre la densidad ósea, evaluada mediante ecografía ósea cuantitativa (QUS), absorciometría de rayos X de energía dual (DXA) y tomografía computarizada cuantitativa periférica (pQCT) y la ingesta alimentaria de cadmio, plomo y mercurio en condiciones saludables. Mujeres premenopáusicas. Un total de 158 mujeres sanas, no fumadoras, premenopáusicas se incorporaron al estudio. Se administró un cuestionario de frecuencia de alimentos validado (FFQ) para evaluar la ingesta durante los siete días anteriores. La mediana pronosticada del consumo de cadmio en la dieta entre las 158 mujeres estudiadas fue de 25.29 g / día (18.62–35.00) y 2.74 g / kg de peso corporal / semana (b.w./w) (1.92–3.83). La ingesta de plomo en la dieta fue de 43.85 g / día (35.09–51.45) y 4.82 g / kg b.w./w (3.67–6.13). La ingesta dietética de mercurio observada fue de 9,55 g / día (7,18 a 13,57) y 1,02 g / kg de peso corporal (0,71 a 1,48). Las comparaciones, en términos de ingesta de metales pesados, no mostraron resultados significativos después de un ajuste adicional para la ingesta de energía. No se observaron correlaciones estadísticamente significativas entre la ingesta de metales pesados y los parámetros QUS, DXA y pQCT. Los niveles de exposición dietética de cadmio, plomo y mercurio estaban principalmente dentro de las recomendaciones. No encontramos asociaciones entre los parámetros QUS, DXA y pQCT y la ingesta dietética de los metales pesados estudiados en mujeres premenopáusicas sanas.The bone is one of the relevant target organs of heavy metals, and heavy metal toxicity is associated with several degenerative processes, such osteoporosis and bone mineral alterations, that could lead to fractures. We aimed to study a presumed relationship between bone density, evaluated by quantitative bone ultrasound (QUS), dual-energy X-ray absorptiometry (DXA) and peripheral quantitative computed tomography (pQCT) and the dietary intake of cadmium, lead and mercury in healthy premenopausal women. A total of 158 healthy, non-smoking, premenopausal women were incorporated into the study. A validated food frequency questionnaire (FFQ) was administered to assess intake during the preceding seven days. The median predicted dietary cadmium intake among the 158 women studied was 25.29 g/day (18.62–35.00) and 2.74 g/kg body weight/week (b.w./w) (1.92–3.83). Dietary lead intake was 43.85 g/day (35.09–51.45) and 4.82 g/kg b.w./w (3.67–6.13). The observed dietary mercury intake was 9.55 g/day (7.18–13.57) and 1.02 g/kg b.w./w (0.71–1.48). Comparisons, in terms of heavy metal intake, showed no significant results after further adjusting for energy intake. No statistically significant correlations between heavy metal intake and the QUS, DXA and pQCT parameters were observed. Levels of dietary exposure of cadmium, lead and mercury were mostly within the recommendations. We did not find associations between the QUS, DXA and pQCT parameters and the dietary intake of the studied heavy metals in healthy premenopausal women.
URI: http://hdl.handle.net/10662/8747
Date: 2017


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