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http://hdl.handle.net/10662/19856
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Campo DC | Valor | idioma |
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dc.contributor.author | Yakhine-Diop, Sokhna M. S. | - |
dc.contributor.author | Rodríguez Arribas, Mario | - |
dc.contributor.author | Canales Cortés, Saray | - |
dc.contributor.author | Martínez Chacón, Guadalupe | - |
dc.contributor.author | Uribe Carretero, Elisabet | - |
dc.contributor.author | Blanco Benítez, Mercedes | - |
dc.contributor.author | Duque González, Gema | - |
dc.contributor.author | Paredes Barquero, Marta | - |
dc.contributor.author | Alegre Cortés, Eva | - |
dc.contributor.author | Climent Mata, Vicente | - |
dc.contributor.author | Aiastui Pujana, Ana | - |
dc.contributor.author | López de Munain, Adolfo | - |
dc.contributor.author | Bravo San Pedro, José Manuel | - |
dc.contributor.author | Niso Santano, Mireia | - |
dc.contributor.author | Fuentes Rodríguez, José Manuel | - |
dc.contributor.author | González Polo, Rosa Ana | - |
dc.date.accessioned | 2024-02-04T20:10:23Z | - |
dc.date.available | 2024-02-04T20:10:23Z | - |
dc.date.issued | 2022 | - |
dc.identifier.uri | http://hdl.handle.net/10662/19856 | - |
dc.description.abstract | Autophagy is a mechanism responsible for the degradation of cellular components to maintain their homeostasis. However, autophagy is commonly altered and compromised in several diseases, including neurodegenerative disorders. Parkinson's disease (PD) can be considered a multifactorial disease because environmental factors, genetic factors, and aging are involved. Several genes are involved in PD pathology, among which the LRRK2 gene and its mutations, inherited in an autosomal dominant manner, are responsible for most genetic PD cases. The R1441G LRRK2 mutation is, after G2019S, the most important in PD pathogenesis. Our results demonstrate a relationship between the R1441G LRRK2 mutation and a mechanistic dysregulation of autophagy that compromises cell viability. This altered autophagy mechanism is associated with organellar stress including mitochondrial (which induces mitophagy) and endoplasmic reticulum (ER) stress, consistent with the fact that patients with this mutation are more vulnerable to toxins related to PD, such as MPP+. | es_ES |
dc.description.sponsorship | This research was supported by the “Instituto de Salud Carlos” III CIBERNED (CB06/05/0041 and PI14/00170) and partially supported by the “Fondo Europeo de Desarrollo Regional” (FEDER) from the European Union. S.M.S.Y-D was supported by CIBERNED. S. C-C and E.U-C are supported by a FPU fellowship (FPU19/04435 and FPU16/00684, respectively) from the Ministerio de Ciencia, Innovación y Universidades, Spain. G. M-C is supported by University of Extremadura (ONCE Foundation). M. B-B is supported by a collaboration grant from the Ministerio de Educación y Formación Profesional, Spain. G. D-G is supported by the Consejería de Educación y Empleo-SEXPE-Fondo Social Europeo (TE-0031-19). M. P-B is a recipient of a fellowship from the “Plan Propio de Iniciación a la Investigación, Desarrollo Tecnológico e Innovación (University of Extremadura)”. E.A-C is supported by a grant (IB18048) from the Junta de Extremadura, Spain. M.N-S and J.M-B. S-P were funded by the “Ramon y Cajal” Program (RYC-2016–20883 and RYC-2018–025099, respectively), Spain. | - |
dc.format.extent | 12 p. | es_ES |
dc.format.mimetype | application/pdf | en_US |
dc.language.iso | eng | es_ES |
dc.publisher | Springer Link | - |
dc.subject | Autofagia | es_ES |
dc.subject | Autophagy | es_ES |
dc.subject | Enfermedad de Parkinson | es_ES |
dc.subject | Parkinson's disease | es_ES |
dc.subject | Disfunción mitocondrial | es_ES |
dc.subject | Mitochondrial dysfunction | es_ES |
dc.subject | MAMs | - |
dc.subject | Neurodegeneration | - |
dc.subject | Neurodegeneración | - |
dc.title | The parkinsonian LRRK2 R1441G mutation shows macroautophagy-mitophagy dysregulation concomitant with endoplasmic reticulum stress | es_ES |
dc.type | article | es_ES |
dc.description.version | peerReviewed | es_ES |
europeana.type | TEXT | en_US |
dc.rights.accessRights | closedAccess | es_ES |
dc.subject.unesco | 2403 Bioquímica | es_ES |
dc.subject.unesco | 3302.90 Ingeniería Bioquímica | es_ES |
dc.subject.unesco | 3207 Patología | es_ES |
europeana.dataProvider | Universidad de Extremadura. España | es_ES |
dc.identifier.bibliographicCitation | Yakhine-Diop SMS, Rodríguez-Arribas M, Canales-Cortés S, Martínez-Chacón G, Uribe-Carretero E, Blanco-Benítez M, Duque-González G, Paredes-Barquero M, Alegre-Cortés E, Climent V, Aiastui A, López de Munain A, Bravo-San Pedro JM, Niso-Santano M, Fuentes JM, González-Polo RA. The parkinsonian LRRK2 R1441G mutation shows macroautophagy-mitophagy dysregulation concomitant with endoplasmic reticulum stress. Cell Biol Toxicol. 2022 Oct;38(5):889-911. doi: 10.1007/s10565-021-09617-w. Epub 2021 May 31. PMID: 34060004. | es_ES |
dc.type.version | publishedVersion | es_ES |
dc.contributor.affiliation | Universidad de Extremadura. Departamento de Bioquímica, Biología Molecular y Genética | es_ES |
dc.contributor.affiliation | Universidad de Extremadura. Departamento de Anatomía, Biología Celular y Zoología | - |
dc.contributor.affiliation | Hospital Universitario Donostia. España | - |
dc.contributor.affiliation | Universidad Complutense de Madrid | - |
dc.contributor.affiliation | Universidad de Extremadura. Instituto Universitario de Investigación Biosanitaria de Extremadura (INUBE) | - |
dc.relation.publisherversion | https://link.springer.com/article/10.1007/s10565-021-09617-w | es_ES |
dc.identifier.doi | 10.1007/s10565-021-09617-w | - |
dc.identifier.publicationtitle | Cell Biology & Toxicology | es_ES |
dc.identifier.publicationissue | 38 | es_ES |
dc.identifier.publicationfirstpage | 889 | es_ES |
dc.identifier.publicationlastpage | 911 | es_ES |
dc.identifier.publicationvolume | 5 | es_ES |
dc.identifier.orcid | 0000-0002-6506-422X | es_ES |
dc.identifier.orcid | 0000-0002-5468-3308 | - |
dc.identifier.orcid | 0000-0002-6301-8828 | - |
dc.identifier.orcid | 0000-0002-5698-8180 | - |
dc.identifier.orcid | 0000-0002-5781-1133 | - |
dc.identifier.orcid | 0000-0001-6910-2089 | - |
dc.identifier.orcid | 0000-0002-0163-2953 | - |
Colección: | DABCZ - Artículos DBYBM - Artículos INUBE - Artículos |
Archivos
Archivo | Descripción | Tamaño | Formato | |
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s10565_021_09617_w.pdf ???org.dspace.app.webui.jsptag.ItemTag.accessRestricted??? | 14,59 MB | Adobe PDF | Descargar Pide una copia |
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