Identificador persistente para citar o vincular este elemento:
http://hdl.handle.net/10662/19930
Títulos: | Altered hematological, biochemical and immunological parameters as predictive biomarkers of severity in experimental myocardial infarction |
Autores/as: | Blázquez Durán, Rebeca Álvarez Pérez, Verónica Antequera Barroso, Juan Antonio Báez Díaz, Claudia Blanco Blázquez, Virginia Maestre, Juan Moreno Lobato, Beatriz López, Esther Marinaro, Federica García Casado, Javier Crisóstomo Ayala, Verónica Sánchez Margallo, Francisco Miguel |
Palabras clave: | Myocardial infarction;Infarto de miocardio;Porcine model;Modelo porcino;Biomarkers;Biomarcadores |
Fecha de publicación: | 2018 |
Editor/a: | Elsevier |
Resumen: | Preclinical studies in cardiovascular medicine are necessary to translate basic research to the clinic. The porcine
model has been widely used to understand the biological mechanisms involved in cardiovascular disorders for
which purpose different closed-chest models have been developed in the last years to mimic the pathophysiological
events seen in human myocardial infarction.
In this work, we studied hematological, biochemical and immunological parameters, as well as Magnetic
resonance derived cardiac function measurements obtained from a swine myocardial infarction model. We
identified some blood parameters which were significantly altered after myocardial infarction induction. More
importantly, these parameters (gamma-glutamyl transferase, glutamic pyruvic transaminase, red blood cell
counts, hemoglobin concentration, hematocrit, platelet count and plateletcrit) correlated positively with cardiac
function, infarct size and/or cardiac enzymes (troponin I and creatine kinase-MB).
Thus several blood-derived parameters have allowed us to predict the severity of myocardial infarction in a
clinically relevant animal model. Therefore, here we provide a simple, affordable and reliable way that could
prove useful in the follow up of myocardial infarction and in the evaluation of new therapeutic strategies in this
animal model. Preclinical studies in cardiovascular medicine are necessary to translate basic research to the clinic. The porcine model has been widely used to understand the biological mechanisms involved in cardiovascular disorders for which purpose different closed-chest models have been developed in the last years to mimic the pathophysiological events seen in human myocardial infarction. In this work, we studied hematological, biochemical and immunological parameters, as well as Magnetic resonance derived cardiac function measurements obtained from a swine myocardial infarction model. We identified some blood parameters which were significantly altered after myocardial infarction induction. More importantly, these parameters (gamma-glutamyl transferase, glutamic pyruvic transaminase, red blood cell counts, hemoglobin concentration, hematocrit, platelet count and plateletcrit) correlated positively with cardiac function, infarct size and/or cardiac enzymes (troponin I and creatine kinase-MB). Thus several blood-derived parameters have allowed us to predict the severity of myocardial infarction in a clinically relevant animal model. Therefore, here we provide a simple, affordable and reliable way that could prove useful in the follow up of myocardial infarction and in the evaluation of new therapeutic strategies in this animal model. |
URI: | http://hdl.handle.net/10662/19930 |
ISSN: | 0165-2427 |
DOI: | 10.1016/j.vetimm.2018.10.007 |
Colección: | DDCEM - Artículos |
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