Please use this identifier to cite or link to this item: http://hdl.handle.net/10662/20104
Title: Variability in histamine receptor genes HRH1, HRH2 and HRH4 in patients with hypersensitivity to NSAIDs
Authors: Ayuso Parejo, Pedro
Blanca, Miguel
Cornejo García, José Antonio
Torres, María José
Doña, Inmaculada
Salas, María
Blanca López, Natalia
Canto Díez, Gabriela
Rondón, Carmen
Campo, Paloma
Laguna, José J.
Fernández, Javier
Martínez, Carmen
García-Agúndez Pérez-Coca, José Augusto
García Martín, Elena
Keywords: Histamina;Histamine;Reacciones de hipersensibilidad;Polimorfismos;Hypersensibility reactions;Polymorphisms;Copy number variations;Variaciones del número de copias;Histamine receptors;Receptores de histamina;HRH1;HRH2;HRH4;NSAIDs
Issue Date: 2013
Publisher: Future Medicine
Abstract: Histamine plays an important role in the pathogenesis of allergic diseases. Genetic variations in histamine receptors (HRH) may influence the expression of allergic diseases. This study analyzes the association between HRH variants and NSAID hypersensitivity reactions. Patients & methods: The authors analyzed copy number variations (CNVs) and common functional SNPs in genes HRH1, HRH2 and HRH4 in 442 unrelated patients with hypersensitivity to NSAIDs and in 414 healthy unrelated controls. Results: The authors identified, both in patients and control subjects, individuals carrying CNVs in HRH genes. The most common genotype corresponded to two copies of each gene, but carriers of one or three copies of HRH1 (5% of individuals), HRH2 (1.1%) and HRH4 genes (0.9%) were also identified. Conclusion: For the first time, we describe CNVs in human HRH genes. Neither common functional SNPs in HRH genes nor CNVs influenced the risk of developing hypersensitivity to NSAIDs.
URI: http://hdl.handle.net/10662/20104
ISSN: 2769-6456
DOI: 10.2217/pgs.13.155
Appears in Collections:DBYBM - Artículos
DTMQU - Artículos

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