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http://hdl.handle.net/10662/20194
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Campo DC | Valor | idioma |
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dc.contributor.author | Ayuso Parejo, Pedro | - |
dc.contributor.author | Blanca López, Natalia | - |
dc.contributor.author | Doña, Inmaculada | - |
dc.contributor.author | Torres Jaén, María José | - |
dc.contributor.author | Guéant Rodríguez, Rosa María | - |
dc.contributor.author | Canto Diez, María Gabriela | - |
dc.contributor.author | Sanak, Marek | - |
dc.contributor.author | Mayorga Mayorga, Cristobalina | - |
dc.contributor.author | Guéant, Jean Louis | - |
dc.contributor.author | Blanca Gómez, Miguel | - |
dc.contributor.author | Cornejo García, José Antonio | - |
dc.date.accessioned | 2024-02-07T09:59:14Z | - |
dc.date.available | 2024-02-07T09:59:14Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0954-7894 | - |
dc.identifier.issn | 1365-2222 | - |
dc.identifier.uri | http://hdl.handle.net/10662/20194 | - |
dc.description.abstract | Non-steroidal anti-inflammatory drugs (NSAIDs) are the medications most frequently involved in hypersensitivity drug reactions. Because NSAIDs are prescribed for many conditions, this is a world-wide problem affecting patients of all ages. Various hypersensitivity reactions have been reported, mainly affecting the skin and/or the respiratory airways. The most frequent of these is acute urticaria, which can be induced by several different NSAIDs. Both specific and non-specific immunological pathways have been proposed as underlying mechanisms. This review presents the clinical phenotypes and the drugs involved in NSAID hypersensitivity. Five major clinical syndromes can be distinguished: aspirin-exacerbated respiratory disease (AERD), aspirin-exacerbated cutaneous disease (AECD), multiple NSAID-induced urticaria/angioedema (MNSAID-UA), single NSAID-IgE reactions and single NSAID T cell responses. However, further classification is possible within these five major entities, by detailed descriptions of the clinical characteristics enabling more phenotypes to be defined. This detailed differentiation now seems required in order to undertake appropriate pharmacogenetic studies. | es_ES |
dc.description.sponsorship | This study was supported by grants from the Spanish Health Ministry Fund for Health (FIS) network RIRAAF (RD12/0013/0001), PI10/01598, PS09/02419 and PI12/02247. M. Blanca is a receiver of a grant from the Region of Lorraine, Nancy, France, G Canto is a receiver of a grant from the Spanish Health Ministry Fund for Health (FIS) PI10/01598, JA. Cornejo-García is a postdoctoral researcher of the Juan de la Cierva Programme from the Spanish Ministry of Science and Innovation and Natalia Blanca-López is a receiver of a grant of Spanish Health Ministry Fund for Health (FIS) PI11-01416. | - |
dc.format.extent | 13 p. | es_ES |
dc.format.mimetype | application/pdf | en_US |
dc.language.iso | eng | es_ES |
dc.publisher | John Wiley & Sons Ltd | es_ES |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Reacciones de hipersensibilidad a fármacos | es_ES |
dc.subject | Hypersesnsitivity drug reactions | es_ES |
dc.subject | Antiinflamatorios no esteroideos | - |
dc.subject | Non-steroidal antiinflammatory drugs | - |
dc.subject | Fenotipo | - |
dc.subject | Phenotype | - |
dc.title | Advanced phenotyping in hypersensitivity drug reactions to NSAIDs | es_ES |
dc.type | article | es_ES |
dc.description.version | peerReviewed | es_ES |
europeana.type | TEXT | en_US |
dc.rights.accessRights | closedAccess | es_ES |
dc.subject.unesco | 3209 Farmacología | es_ES |
dc.subject.unesco | 2302 Bioquímica | es_ES |
europeana.dataProvider | Universidad de Extremadura. España | es_ES |
dc.identifier.bibliographicCitation | P. Ayuso, N. Blanca-López, I. Doña, M. J. Torres, R. M. Guéant-Rodríguez, G. Canto, M. Sanak, C. Mayorga, J. L. Guéant, M. Blanca, J. A. Cornejo-García. Clinical & Experimental Allergy, 2013 ( 43) 1097–1109. https://doi.org/10.1111/cea.12140 | - |
dc.type.version | publishedVersion | es_ES |
dc.contributor.affiliation | Universidad de Extremadura. Departamento de Terapéutica Médico-Quirúrgica | es_ES |
dc.contributor.affiliation | Hospital Infanta Leonor. Madrid | - |
dc.contributor.affiliation | Université Nancy. Francia | - |
dc.contributor.affiliation | Jagiellonian University Medical College. Polonia | - |
dc.relation.publisherversion | https://onlinelibrary.wiley.com/doi/10.1111/cea.12140 | es_ES |
dc.identifier.doi | 10.1111/cea.12140 | - |
dc.identifier.publicationtitle | Clinical & Experimental Allergy | es_ES |
dc.identifier.publicationissue | 10 | - |
dc.identifier.publicationfirstpage | 1097 | es_ES |
dc.identifier.publicationlastpage | 1109 | es_ES |
dc.identifier.publicationvolume | 43 | es_ES |
dc.identifier.orcid | 0000-0002-9441-4022 | es_ES |
Colección: | DTMQU - Artículos |
Archivos
Archivo | Descripción | Tamaño | Formato | |
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cea_12140.pdf ???org.dspace.app.webui.jsptag.ItemTag.accessRestricted??? | 243,53 kB | Adobe PDF | Descargar Pide una copia |
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