Please use this identifier to cite or link to this item:
http://hdl.handle.net/10662/20471
Title: | Molecular mechanisms of lncRNAs in the dependent regulation of cancer and their potential therapeutic use |
Authors: | Garcia Padilla, Carlos García López, Virginio Aranega, Amelia Franco, Diego García Martínez, Virginio Enrique López Sánchez, Carmen |
Keywords: | Enfermedad del cáncer;Cancer disease;ARN largos no codificantes;Medicamentos terapéuticos;Long non-coding RNAs;lncRNAs;Therapeutic drugs |
Issue Date: | 2022 |
Publisher: | MDPI |
Abstract: | Deep whole genome and transcriptome sequencing have highlighted the importance of an emerging class of non-coding RNA longer than 200 nucleotides (i.e., long non-coding RNAs (lncRNAs)) that are involved in multiple cellular processes such as cell differentiation, embryonic development, and tissue homeostasis. Cancer is a prime example derived from a loss of homeostasis, primarily caused by genetic alterations both in the genomic and epigenetic landscape, which results in deregulation of the gene networks. Deregulation of the expression of many lncRNAs in samples, tissues or patients has been pointed out as a molecular regulator in carcinogenesis, with them acting as oncogenes or tumor suppressor genes. Herein, we summarize the distinct molecular regulatory mechanisms described in literature in which lncRNAs modulate carcinogenesis, emphasizing epigenetic and genetic alterations in particular. Furthermore, we also reviewed the current strategies used to block lncRNA oncogenic functions and their usefulness as potential therapeutic targets in several carcinomas. |
URI: | http://hdl.handle.net/10662/20471 |
ISSN: | 1661-6596 |
DOI: | 10.3390/ijms23020764 |
Appears in Collections: | DABCZ - Artículos IBPM - Artículos |
Files in This Item:
File | Description | Size | Format | |
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ijms23020764.pdf | 1,31 MB | Adobe PDF | View/Open |
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