Identificador persistente para citar o vincular este elemento:
http://hdl.handle.net/10662/20528
Títulos: | Participation of MT3 melatonin receptors in the synergistic effect of melatonin on cytotoxic and apoptotic actions evoked by chemotherapeutics |
Autores/as: | Bejarano Hernando, Ignacio Pariente Rodríguez, Roberto Espino Palma, Javier Rodríguez Moratinos, Ana Beatriz Pariente Llanos, José Antonio |
Palabras clave: | Melatonin;Melatonina;Chemotherapy;Quimioterapia;Oncology;Oncología |
Fecha de publicación: | 2017-09-27 |
Editor/a: | Springer |
Resumen: | Melatonin has antitumor activity via several mechanisms including its antiproliferative and proapoptotic effects in addition to its potent antioxidant actions. Therefore, melatonin may be useful in the treatment of tumors in association with chemotherapy drugs. This study was performed to study the role of melatonin receptors on the cytotoxicity and apoptosis induced by the chemotherapeutic agents cisplatin and 5-fluorouracil in two tumor cell lines, such as human colorectal cancer HT-29 cells and cervical cancer HeLa cells. |
URI: | http://hdl.handle.net/10662/20528 |
ISSN: | 0344-5704 |
DOI: | 10.1007/s00280-017-3441-3 |
Colección: | DFSIO - Artículos |
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