Please use this identifier to cite or link to this item:
http://hdl.handle.net/10662/20943
Title: | Oral melatonin administration and programmed cell death of neutrophils, lymphocytes, and other cell types from rats injected with HL-60 cells |
Authors: | Delgado Adámez, Jonathan Terrón Sánchez, María del Pilar García Martínez, Virginio Enrique López Sánchez, Carmen Barriga Ibars, Carmen Pariente Llanos, José Antonio Rodríguez Moratinos, Ana Beatriz |
Keywords: | Melatonina;Melatonin;Neutrófilos;Linfocitos;Apoptosis;Células HL-60;Neutrophils;Lymphocytes;HL-60 cells |
Issue Date: | 2011 |
Publisher: | University of South Bohemia |
Abstract: | Recent years have seen mounting evidence for the role of melatonin in mediating programmed cell death, with a protective, anti-apoptotic effect in healthy cells, but an anti-tumoural, pro-apoptotic action in many tumour cells. In this study, we evaluated the effect of melatonin on the programmed cell death induced by thapsigargin (TG), on lymphocytes and neutrophils, and on various tissues obtained from rats injected with human promyelocytic leukæmia cells (HL-60), treated with melatonin in their drinking water (20 μm), and fed ad libitum. Melatonin treatment significantly reduced caspase-3 and −9 activity, and caused the proportions of lymphocytes, neutrophils, and eosinophils to revert to their basal values. No histological differences were observed. In conclusion, melatonin has anti-apoptotic effects on lymphocytes and neutrophils obtained from rats injected with HL-60 leukæmia cells. |
URI: | http://hdl.handle.net/10662/20943 |
ISSN: | 1214-021X |
DOI: | 10.2478/v10136-011-0006-3 |
Appears in Collections: | DABCZ - Artículos DFSIO - Artículos |
Files in This Item:
File | Description | Size | Format | |
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v10136-011-0006-3.pdf | 3,28 MB | Adobe PDF | View/Open |
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