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http://hdl.handle.net/10662/21312
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Campo DC | Valor | idioma |
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dc.contributor.author | Sánchez Terrón, María Guadalupe | - |
dc.contributor.author | Martínez Pérez, Remigio | - |
dc.contributor.author | Ruiz Carrascal, Jorge | - |
dc.contributor.author | Luna Estellés, Carolina Luisa | - |
dc.contributor.author | Estévez García, Mario | - |
dc.date.accessioned | 2024-05-24T08:50:57Z | - |
dc.date.available | 2024-05-24T08:50:57Z | - |
dc.date.issued | 2023 | - |
dc.identifier.uri | http://hdl.handle.net/10662/21312 | - |
dc.description.abstract | The gastrointestinal tract (GIT) is the target of assorted pathological conditions, and dietary components are known to affect its functionality and health. In previous in vitro studies, we observed that reducing sugars induced protein glycoxidation and impaired protein digestibility. To gain further insights into the pathophysiological effects of dietary sugars, Wistar rats were provided with a 30% (w/v) fructose water solution for 10 weeks. Upon slaughter, in vivo protein digestibility was assessed, and the entire GIT (digests and tissues) was analyzed for markers of oxidative stress and untargeted metabolomics. Additionally, the impact of sustained fructose intake on colonic microbiota was also evaluated. High fructose intake for 10 weeks decreased protein digestibility and promoted changes in the physiological digestion of proteins, enhancing intestinal digestion rather than stomach digestion. Moreover, at colonic stages, the oxidative stress was harmfully increased, and both the microbiota and the intraluminal colonic metabolome were modified. | es_ES |
dc.description.sponsorship | The study was funded by “Junta de Extremadura” (IB20103), the Ministry of Science and Innovation, (MCIN/AEI/10.13039/501100011033; PID2021-126193OB-I00), and the UEx (UNEX-AE-3394). Guadalupe Sánchez thanks the Spanish Ministry of Universities for her FPU grant (FPU18/0177). R.M. was supported by a postdoctoral contract Margarita Salas Reference MS-23 (University of Extremadura) from the Program of Requalification of the Spanish University System (Spanish Ministry of Universities) financed by the European Union-NextGenerationEU. | es_ES |
dc.format.extent | 16 p. | es_ES |
dc.format.medium | application/pdf | en_US |
dc.language.iso | eng | es_ES |
dc.publisher | ACS Publications | es_ES |
dc.rights | Attribution 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Fructosa | es_ES |
dc.subject | Metabolómico | es_ES |
dc.subject | Microbiota | es_ES |
dc.subject | Digestibilidad de las proteínas | es_ES |
dc.subject | Glucoxidación de proteínas | es_ES |
dc.subject | Fructose | es_ES |
dc.subject | Metabolomic | es_ES |
dc.subject | Protein digestibility | es_ES |
dc.subject | Protein glycoxidation | es_ES |
dc.title | Impact of sustained fructose consumption on gastrointestinal function and health in wistar rats: glycoxidative stress, impaired protein digestion, and shifted fecal microbiota | es_ES |
dc.type | article | es_ES |
dc.description.version | peerReviewed | es_ES |
europeana.type | TEXT | en_US |
dc.rights.accessRights | openAccess | es_ES |
dc.subject.unesco | 2302.27 Proteínas | es_ES |
dc.subject.unesco | 2401.11 Patología Animal | es_ES |
dc.subject.unesco | 2411.07 Fisiología de la Digestión | es_ES |
europeana.dataProvider | Universidad de Extremadura. España | es_ES |
dc.identifier.bibliographicCitation | Guadalupe Sánchez-Terrón, Remigio Martínez, Jorge Ruiz, Carolina Luna, and Mario Estévez. Impact of Sustained Fructose Consumption on Gastrointestinal Function and Health in Wistar Rats: Glycoxidative Stress, Impaired Protein Digestion, and Shifted Fecal Microbiota. Journal of Agricultural and Food Chemistry 2023 71 (43), 16270-16285 DOI: 10.1021/acs.jafc.3c04515 | es_ES |
dc.type.version | publishedVersion | es_ES |
dc.contributor.affiliation | Universidad de Extremadura. Instituto Universitario de Investigación de Carne y Productos Cárnicos (IPROCAR) | es_ES |
dc.contributor.affiliation | Universidad de Extremadura. Departamento de Sanidad Animal | es_ES |
dc.relation.publisherversion | https://pubs.acs.org/doi/full/10.1021/acs.jafc.3c04515 | es_ES |
dc.identifier.doi | 10.1021/acs.jafc.3c04515 | - |
dc.identifier.publicationtitle | Journal of Agricultural and Food Chemistry | es_ES |
dc.identifier.publicationissue | 43 | es_ES |
dc.identifier.publicationfirstpage | 16270 | es_ES |
dc.identifier.publicationlastpage | 16285 | es_ES |
dc.identifier.publicationvolume | 71 | es_ES |
dc.identifier.orcid | 0000-0003-0838-3803 | es_ES |
dc.identifier.orcid | 0000-0002-5908-9447 | es_ES |
dc.identifier.orcid | 0000-0001-7905-3153 | es_ES |
dc.identifier.orcid | 0000-0002-8509-2789 | es_ES |
Colección: | DSANI - Artículos IProCar - Artículos |
Archivos
Archivo | Descripción | Tamaño | Formato | |
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acs_jafc_3c04515.pdf | 2,96 MB | Adobe PDF | Descargar |
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