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http://hdl.handle.net/10662/21358
Títulos: | Urinary cystatin C and N-acetyl-beta-D-glucosaminidase (NAG) as early biomarkers for renal disease in dogs with leishmaniosis |
Autores/as: | Ruiz Tapia, Patricia Durán Galea, Ángela Duque Carrasco, Francisco Javier González, Mario Alberto Cristóbal Verdejo, José Ignacio Nicolás Barceló, Paloma Pérez Merino, Eva María Macías García, Beatriz Barrera Chacón, Rafael |
Palabras clave: | Leishmaniosis canina;Biomarcadores;Cistatina C;N-acetil-beta-D-glucosaminidasa (NGA);Canine leishmaniasis;Biomarkers;Cystatin C;N-acetyl-beta-Dglucosaminidase (NAG), |
Fecha de publicación: | 2023 |
Editor/a: | Elsevier |
Resumen: | Canine leishmaniasis (CanL) is a disease caused by Leishmania infantum that can vary from a subclinical infection to a severe disease. Dogs affected with CanL present varying degrees of renal dysfunction. Unfortunately, traditional biomarkers such as urea and creatinine detect renal damage in advanced stages of the disease, so more accurate biomarkers are needed. Hence, we aimed to study how urinary cystatin C (CysC) and N-acetyl-beta-Dglucosaminidase (NAG), behave in dogs with CanL at different stages of the disease. Eighty-six CanL infected dogs were classified according to LeishVet stages: LI (16 dogs), LIIa (12 dogs), LIIb (12 dogs), LIII (16 dogs) and LIV (30 dogs); as a control, 17 healthy dogs were studied. Blood samples were collected for complete haematological and biochemistry analysis including plasma cystatin C. Urine analysis included urine specific gravity (USG), urine protein to creatinine ratio (UPC), CysC and NAG expressed as a ratio with creatinine uCysCc (μg/g) and uNAGc (IU/g). The haematological, biochemical and urinary analysis coincided with the LeishVet guidelines. The statistical study of the uCysCc ratio and the uNAGc, showed significant increase when compared against control starting from group LI (p < 0.05). Interestingly, when the cut-off values were calculated using the ROC curve, uCysCc (258.85 μg/g) and uNAGc (2.25 IU/g) 75 % of the dogs included in LI groups surpassed the threshold. Hence our study indicates that uCysCc and uNAGc, could help to detect early renal damage in CanL affected dogs. |
URI: | http://hdl.handle.net/10662/21358 |
ISSN: | 0304-4017 |
DOI: | 10.1016/j.vetpar.2023.109930 |
Colección: | DMANI - Artículos |
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