Please use this identifier to cite or link to this item:
http://hdl.handle.net/10662/22099
Title: | Synthesis of Chromeno[3,4-b]piperazines by an Enol-Ugi/Reduction/Cyclization Sequence |
Authors: | Bornadiego Suárez, Ana Gómez Neo, Ana María Fernández Marcos, Carlos María |
Keywords: | Reacciones multicomponentes;Isocianuros;Peptidomimético;Heterociclos;Piperazinas;Pirazinas;Cromonas;Cumarinas;Enoles;Reacción de Ugi;Imulticomponent reactions;Peptidomimetics;isocyanides;Heterocycles;Piperazines;Chromones;Coumarins;Enols;Ugi reaction |
Issue Date: | 2021 |
Publisher: | MDPI |
Abstract: | Keto piperazines and aminocoumarins are privileged building blocks for the construction of geometrically constrained peptides and therefore valuable structures in drug discovery. Combining these two heterocycles provides unique rigid polycyclic peptidomimetics with drug-like properties including many points of diversity that could be modulated to interact with different biological receptors. This work describes an efficient multicomponent approach to condensed chromenopiperazines based on the novel enol-Ugi reaction. Importantly, this strategy involves the first reported post-condensation transformation of an enol-Ugi adduct. |
URI: | http://hdl.handle.net/10662/22099 |
DOI: | 10.3390/molecules26051287 |
Appears in Collections: | DQOIN - Artículos |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
molecules26051287.pdf | 868,45 kB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License