Identificador persistente para citar o vincular este elemento:
http://hdl.handle.net/10662/19856
Títulos: | The parkinsonian LRRK2 R1441G mutation shows macroautophagy-mitophagy dysregulation concomitant with endoplasmic reticulum stress |
Autores/as: | Yakhine-Diop, Sokhna M. S. Rodríguez Arribas, Mario Canales Cortés, Saray Martínez Chacón, Guadalupe Uribe Carretero, Elisabet Blanco Benítez, Mercedes Duque González, Gema Paredes Barquero, Marta Alegre Cortés, Eva Climent Mata, Vicente Aiastui Pujana, Ana López de Munain, Adolfo Bravo San Pedro, José Manuel Niso Santano, Mireia Fuentes Rodríguez, José Manuel González Polo, Rosa Ana |
Palabras clave: | Autofagia;Autophagy;Enfermedad de Parkinson;Parkinson's disease;Disfunción mitocondrial;Mitochondrial dysfunction;MAMs;Neurodegeneration;Neurodegeneración |
Fecha de publicación: | 2022 |
Editor/a: | Springer Link |
Resumen: | Autophagy is a mechanism responsible for the degradation of cellular components to maintain their homeostasis. However, autophagy is commonly altered and compromised in several diseases, including neurodegenerative disorders. Parkinson's disease (PD) can be considered a multifactorial disease because environmental factors, genetic factors, and aging are involved. Several genes are involved in PD pathology, among which the LRRK2 gene and its mutations, inherited in an autosomal dominant manner, are responsible for most genetic PD cases. The R1441G LRRK2 mutation is, after G2019S, the most important in PD pathogenesis. Our results demonstrate a relationship between the R1441G LRRK2 mutation and a mechanistic dysregulation of autophagy that compromises cell viability. This altered autophagy mechanism is associated with organellar stress including mitochondrial (which induces mitophagy) and endoplasmic reticulum (ER) stress, consistent with the fact that patients with this mutation are more vulnerable to toxins related to PD, such as MPP+. |
URI: | http://hdl.handle.net/10662/19856 |
DOI: | 10.1007/s10565-021-09617-w |
Colección: | DABCZ - Artículos DBYBM - Artículos INUBE - Artículos |
Archivos
Archivo | Descripción | Tamaño | Formato | |
---|---|---|---|---|
s10565_021_09617_w.pdf ???org.dspace.app.webui.jsptag.ItemTag.accessRestricted??? | 14,59 MB | Adobe PDF | Descargar Pide una copia |
Este elemento está sujeto a una licencia Licencia Creative Commons