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http://hdl.handle.net/10662/21312
Title: | Impact of sustained fructose consumption on gastrointestinal function and health in wistar rats: glycoxidative stress, impaired protein digestion, and shifted fecal microbiota |
Authors: | Sánchez Terrón, María Guadalupe Martínez Pérez, Remigio Ruiz Carrascal, Jorge Luna Estellés, Carolina Luisa Estévez García, Mario |
Keywords: | Fructosa;Metabolómico;Microbiota;Digestibilidad de las proteínas;Glucoxidación de proteínas;Fructose;Metabolomic;Protein digestibility;Protein glycoxidation |
Issue Date: | 2023 |
Publisher: | ACS Publications |
Abstract: | The gastrointestinal tract (GIT) is the target of assorted pathological conditions, and dietary components are known to affect its functionality and health. In previous in vitro studies, we observed that reducing sugars induced protein glycoxidation and impaired protein digestibility. To gain further insights into the pathophysiological effects of dietary sugars, Wistar rats were provided with a 30% (w/v) fructose water solution for 10 weeks. Upon slaughter, in vivo protein digestibility was assessed, and the entire GIT (digests and tissues) was analyzed for markers of oxidative stress and untargeted metabolomics. Additionally, the impact of sustained fructose intake on colonic microbiota was also evaluated. High fructose intake for 10 weeks decreased protein digestibility and promoted changes in the physiological digestion of proteins, enhancing intestinal digestion rather than stomach digestion. Moreover, at colonic stages, the oxidative stress was harmfully increased, and both the microbiota and the intraluminal colonic metabolome were modified. |
URI: | http://hdl.handle.net/10662/21312 |
DOI: | 10.1021/acs.jafc.3c04515 |
Appears in Collections: | DSANI - Artículos IProCar - Artículos |
Files in This Item:
File | Description | Size | Format | |
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acs_jafc_3c04515.pdf | 2,96 MB | Adobe PDF | View/Open |
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